MIOS Antibody

Datasheet
Code CSB-PA865167LA01HU
Size US$299
Uniprot No. Q9NXC5
Image
  • IHC image of CSB-PA865167LA01HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunogen Recombinant Human GATOR complex protein MIOS protein (1-237AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Relevance As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias GATOR complex protein MIOS (Missing oocyte meiosis regulator homolog), MIOS
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Research Area Cell Biology
Target Names MIOS
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex
Subcellular Location Lysosome membrane
Protein Families WD repeat mio family
Database Links

HGNC: 21905

OMIM: 615359

KEGG: hsa:54468

STRING: 9606.ENSP00000339881

UniGene: Hs.520215

Pathway mTOR signaling pathway

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