MLLT4 Antibody, Biotin conjugated

Code CSB-PA014636LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AFDN Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
AF6 antibody; AFAD_HUMAN antibody; Afadin antibody; ALL1-fused gene from chromosome 6 protein antibody; Mllt4 antibody; Protein Af-6 antibody; Protein AF6 antibody
Raised in
Species Reactivity
Recombinant Human Afadin protein (1663-1809AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions.
Gene References into Functions
  1. CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells. PMID: 29159771
  2. AF6 employs a non-canonical, evolutionarily conserved alpha-helix to bind RAS, unique to AF6 and the classical RASSF effectors. PMID: 29062045
  3. miR-188-3p is a novel independent prognostic factor in colorectal cancer patients, which can be partly explained by its effect on MLLT4 expression and migration of cancer cells. PMID: 27601590
  4. Afadin (AFDN), a cytoskeletal and junction-associated protein, was present in 2D and 3D keratinocyte cultures, and validated as a so-far-unknown EphA2-interacting protein. PMID: 27815408
  5. In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1-induced trans-activation of Snail, which promotes proliferation and metastasis. PMID: 26013125
  6. AF-6/afadin could be a useful selection marker for fertility-sparing therapy for patients with atypical hyperplasia or grade 1 endometrioid adenocarcinoma with no myometrial invasion. PMID: 25879875
  7. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. PMID: 23885123
  8. The expression levels of CFTR and AF-6/afadin are significantly downregulated in human colon cancer tissues. PMID: 24373847
  9. AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease. PMID: 23393160
  10. The interaction between the PDZ domain of afadin (AF6_PDZ) and a series of polypeptides comprising the PDZ-binding motif, was studied. PMID: 20586101
  11. Results demonstrate a role for afadin in the regulation of vascular barrier function via coordination of adherens junction-tight junction and p120-catenin-ZO-1 interactions. PMID: 21732359
  12. the Necl-5-nectin, nectin-nectin, and nectin-afadin interactions cooperatively increase the clustering of the nectin-afadin complex at the cell-cell contact sites, promoting the formation of the nectin-based cell-cell adhesion. PMID: 21880730
  13. AF6/afadin is a marker of poor outcome in breast cancer, and its loss induces cell migration, invasiveness and tumor growth PMID: 21478912
  14. Results demonstrate a novel molecular mechanism by which Rap1 and afadin regulate the VEGF- and S1P-induced angiogenesis. PMID: 20413783
  15. RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6. PMID: 11956217
  16. Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain PMID: 12808105
  17. Results report the solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr. PMID: 15684424
  18. AF6 negatively regulates Rap1-induced cell adhesion. PMID: 16051602
  19. Loss of afadin is associated with breast cancer PMID: 16819513
  20. AF6/s-afadin is a candidate for mediating control of cellular growth processes by regulated translocation to the nucleus. PMID: 17013812
  21. c-Src is recruited by AF-6 to cell-cell contact sites, suggesting that c-Src is regulated by a PDZ protein in special cellular locations. PMID: 17491594
  22. AF6 protein is important for spreading of Herpes simplex virus 1 in epithelial cells PMID: 17967423
  23. two distal surfaces of the AF-6 PDZ domain respond differently to peptide binding; distal surface 1 changes in millisecond dynamics, whereas distal surface 2 undergoes structural rearrangement PMID: 18052198
  24. This paper deals with AF-6 in mouse, rat, and cow. PMID: 9722616

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Involvement in disease
A chromosomal aberration involving AFDN is associated with acute leukemias. Translocation t(6;11)(q27;q23) with KMT2A/MLL1. The result is a rogue activator protein.
Subcellular Location
Cell junction, adherens junction.
Database Links

HGNC: 7137

OMIM: 159559

KEGG: hsa:4301

STRING: 9606.ENSP00000375956

UniGene: Hs.614974

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