MLXIP Antibody

1. Data (including data from studies in knockout mice) suggest that MONDOA shuttles to nucleus of pancreatic beta-cells where it is required for induction of glucose-responsive genes arrestin domain-containing protein 4 (ARRDC4) and thioredoxin interacting protein (TXNIP). PMID: 29282201
2. MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin signaling PMID: 27500491
3. Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism. PMID: 26910886
4. These results suggest that C771G polymorphism of MLXIPL gene is associated with coronary stenosis and its severity. PMID: 25179879
5. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in apoptosis PMID: 25640402
6. An important contribution of MondoA to leukemia aggressiveness, which makes MondoA a potential candidate for targeted treatment of acute lymphoblastic leukemia. PMID: 22748921
7. Glucose is required at two additional steps to stimulate the transcription activation function of MondoA-Mlx complexes. PMID: 20385767
8. Data show that for both MondoA and Mlx, the C-terminal domain CRM-1 has cytoplasmic localization activity that is required by the protein monomers to accumulate in the cytoplasm. PMID: 12446771
9. Endogenous MondoA and Mlx associate with mitochondria in primary skeletal muscle. PMID: 16782875
10. Data suggest that glutamine-dependent mitochondrial anapleurosis dictates glucose uptake and aerobic glycolysis by blocking MondoA:Mlx-dependent transcriptional activation of TXNIP. PMID: 19706488

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HGNC: 17055

OMIM: 608090

KEGG: hsa:22877

STRING: 9606.ENSP00000312834

UniGene: Hs.437153