MMP15 Antibody

1. identify an MT2-MMP-E-cadherin axis that functions as a novel regulator of epithelial cell homeostasis in vivo PMID: 29061881
2. Results suggest that MT2-MMP degrades adherens and tight junction proteins and results in EMT, making it a potential mediator of EMT in carcinomas. PMID: 27374080
3. TCF-4 is a co-activator of NF-kappaB p65 that promotes MMP-15 transcription and potentiate the migration activity of the lung cancer cells PMID: 27046058
4. In conclusion, MT2-MMP is involved in gastric cancer invasion and metastasis and may serve as an independent prognostic factor for gastric cancer patients. PMID: 25973093
5. our data suggest that MT2-MMP expression positively involves in non-small cell lung cancer and might play an important role in promoting the tumor progression and intra-tumoral angiogenesis PMID: 25031779
6. HLA-G expression involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer. PMID: 23228395
7. MMP-15 is up-regulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin. PMID: 22768148
8. MMP-15 and MMP-19 are upregulated during colorectal tumorigenesis PMID: 22576687
9. Data show that MT2-MMP was a novel hypoxia-responsive gene and was upregulated by HIF-1alpha under hypoxia. PMID: 21751260
10. The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues. PMID: 21036765
11. MMP2 activity is associated with an increase in MT2-MMP expression and with lymph node metastasis. PMID: 20586027
12. These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP independently of MMP-2 and MT1-MMP. PMID: 20117087
13. Data show that the MT2-MMP catalytic domain has a higher propensity than that of MT1-MMP to initiate cleavage of the MMP-2 prodomain in the absence of TIMP-2. PMID: 16825197
14. Type-2 metalloproteinases, are identified as the triggering agents that independently confer cancer cells with the ability to proteolytically efface the BM scaffolding, initiate the assembly of invasive pseudopodia, and propagate transmigration. PMID: 16983145
15. Data show that MMP15 may be relevant with carcinogenesis, development and metastasis of adenoid cystic carcinoma, and different metastasis potential may result from different subtype of MMPs gene family. PMID: 17029196

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HGNC: 7161

OMIM: 602261

KEGG: hsa:4324

STRING: 9606.ENSP00000219271

UniGene: Hs.80343