MMP21 Antibody

Datasheet

Code	CSB-PA729577
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA729577(MMP21 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA729577(MMP21 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8N119

Target Names

MMP21

Alternative Names

MMP21Matrix metalloproteinase-21 antibody; MMP-21 antibody; EC 3.4.24.- antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human MMP21

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin.

Gene References into Functions

MMP-21 572TT genotype increased the risk for the HIV-associated neurocognitive disorder. PMID: 29575199
loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. PMID: 26429889
Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance. PMID: 26437028
Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and lymph node metastasis. PMID: 25015395
These results suggest that high MMP-21 expression in lymph node metastatic foci can be used to predict survival in OSCC patients with LNM PMID: 24700287
analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients PMID: 23275114
MMP-21 expression is elevated in primary CRC and related to tumor invasion and metastasis. MMP-21 was also proved to be an independent prognostic factor for patients with stage II and stage III colorectal cancer. PMID: 21656525
MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation. PMID: 19601983
MMP-21 was expressed by Merkel cell carcinoma cells in 13/43 cases and in eight samples by stromal neutrophils. None of the samples with MMP-21-expressing neutrophils had metastasized to the lymph nodes PMID: 19921252
The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer. PMID: 15015597
MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer PMID: 17873896
MMP-21 may be an important protease in the terminal differentiation of keratinocytes PMID: 18633436
A nonsynchronous polymorphism in the MMP-21 promoter does not significantly confer susceptibility to hepatocellular carcinoma in a southern Chinese population. PMID: 18768525

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Involvement in disease

Heterotaxy, visceral, 7, autosomal (HTX7)

Subcellular Location

Secreted.

Protein Families

Peptidase M10A family

Tissue Specificity

Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.

Database Links

HGNC: 14357

OMIM: 608416

KEGG: hsa:118856

STRING: 9606.ENSP00000357798

UniGene: Hs.314141

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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