Human Matrix metalloproteinase-21(MMP21) ELISA kit

Instructions
Code CSB-EL014668HU
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name matrix metallopeptidase 21
Alternative Names MMP21Matrix metalloproteinase-21 ELISA Kit; MMP-21 ELISA Kit; EC 3.4.24.- ELISA Kit
Abbreviation MMP21
Uniprot No. Q8N119
Species Homo sapiens (Human)
Sample Types serum, plasma,tissue homogenates
Detection Range 1.56 ng/mL-100 ng/mL
Sensitivity 0.39 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cancer
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Data

Function Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway
Gene References into Functions
  1. MMP-21 572TT genotype increased the risk for the HIV-associated neurocognitive disorder. PMID: 29575199
  2. loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. PMID: 26429889
  3. Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance. PMID: 26437028
  4. Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and lymph node metastasis. PMID: 25015395
  5. These results suggest that high MMP-21 expression in lymph node metastatic foci can be used to predict survival in OSCC patients with LNM PMID: 24700287
  6. analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients PMID: 23275114
  7. MMP-21 expression is elevated in primary CRC and related to tumor invasion and metastasis. MMP-21 was also proved to be an independent prognostic factor for patients with stage II and stage III colorectal cancer. PMID: 21656525
  8. MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation. PMID: 19601983
  9. MMP-21 was expressed by Merkel cell carcinoma cells in 13/43 cases and in eight samples by stromal neutrophils. None of the samples with MMP-21-expressing neutrophils had metastasized to the lymph nodes PMID: 19921252
  10. The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer. PMID: 15015597
  11. MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer PMID: 17873896
  12. MMP-21 may be an important protease in the terminal differentiation of keratinocytes PMID: 18633436
  13. A nonsynchronous polymorphism in the MMP-21 promoter does not significantly confer susceptibility to hepatocellular carcinoma in a southern Chinese population. PMID: 18768525

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Involvement in disease Heterotaxy, visceral, 7, autosomal (HTX7)
Subcellular Location Secreted
Protein Families Peptidase M10A family
Tissue Specificity Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
Database Links

HGNC: 14357

OMIM: 608416

KEGG: hsa:118856

STRING: 9606.ENSP00000357798

UniGene: Hs.314141

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