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Human Matrix metalloproteinase-21(MMP21) ELISA kit

Human Matrix metalloproteinase-21(MMP21) ELISA kit

Citations (1) Protocol MSDS

Code	CSB-EL014668HU
Size	96T,5×96T,10×96T
Price	Request a Quote or Start an on-line Chat
Trial Size	24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details
Citations (1)
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Target Background

Product Details

Target Name

matrix metallopeptidase 21

Alternative Names

MMP21Matrix metalloproteinase-21 ELISA Kit; MMP-21 ELISA Kit; EC 3.4.24.- ELISA Kit

Abbreviation

MMP21

Uniprot No.

Q8N119

Species

Homo sapiens (Human)

Sample Types

serum, plasma,tissue homogenates

Detection Range

1.56 ng/mL-100 ng/mL

Sensitivity

0.39 ng/mL

Assay Time

1-5h

Sample Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Cancer

Assay Principle

quantitative

Measurement

Sandwich

ELISA Data Analysis

ELISA Standard Curve & Curve Expert software

Troubleshooting
and FAQs

ELISA kit FAQs

Storage

Store at 2-8°C. Please refer to protocol.

Lead Time

3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

Description

This Human MMP21 ELISA Kit was designed for the quantitative measurement of Human MMP21 protein in serum, plasma,tissue homogenates. It is a Sandwich ELISA kit, its detection range is 1.56 ng/mL-100 ng/mL and the sensitivity is 0.39 ng/mL.

Citations

ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21 Y Xiang,Cancer Cell International,2020

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Target Background

Function
(From Uniprot)

Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin.

Gene References into Functions

MMP-21 572TT genotype increased the risk for the HIV-associated neurocognitive disorder. PMID: 29575199
loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. PMID: 26429889
Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance. PMID: 26437028
Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and lymph node metastasis. PMID: 25015395
These results suggest that high MMP-21 expression in lymph node metastatic foci can be used to predict survival in OSCC patients with LNM PMID: 24700287
analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients PMID: 23275114
MMP-21 expression is elevated in primary CRC and related to tumor invasion and metastasis. MMP-21 was also proved to be an independent prognostic factor for patients with stage II and stage III colorectal cancer. PMID: 21656525
MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation. PMID: 19601983
MMP-21 was expressed by Merkel cell carcinoma cells in 13/43 cases and in eight samples by stromal neutrophils. None of the samples with MMP-21-expressing neutrophils had metastasized to the lymph nodes PMID: 19921252
The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer. PMID: 15015597
MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer PMID: 17873896
MMP-21 may be an important protease in the terminal differentiation of keratinocytes PMID: 18633436
A nonsynchronous polymorphism in the MMP-21 promoter does not significantly confer susceptibility to hepatocellular carcinoma in a southern Chinese population. PMID: 18768525

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Involvement in disease

Heterotaxy, visceral, 7, autosomal (HTX7)

Subcellular Location

Secreted.

Protein Families

Peptidase M10A family

Tissue Specificity

Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.

Database Links

HGNC: 14357

OMIM: 608416

KEGG: hsa:118856

STRING: 9606.ENSP00000357798

UniGene: Hs.314141

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ELISA Data Analysis How to Do The Pre-experiment before Your ELISA Experiment Four Types of ELISA 11 tips for choosing your right ELISA kit Do you Often Trouble in These Problems of ELISA? Problems and Solutions in ELISA Experiments

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Human Matrix metalloproteinase-21(MMP21) ELISA kit

Product Details

Citations

Related Products

Customer Reviews and Q&A

Target Background