MN1 Antibody

1. Study suggests a role for DNMT3B in leukemogenesis in inv(16) acute myeloid leukemia, through MN1 methylation regulation. PMID: 28892045
2. The data obtained show that normal cells consistently express low levels of MN1 transcript. In contrast, high levels of MN1 expression are present in 47% of patients with normal karyotype and in all cases with inv(16). PMID: 27765915
3. Patients with t(12;22)/MN1-EVT6 oncogene, are frequently associated with myeloid neoplasms, poor response to chemotherapy, and inferior outcome. PMID: 29273914
4. MN1 gene expression in acute myeloid leukemia. PMID: 27983532
5. MN1 deletion is associated with Craniofacial Abnormalities. PMID: 26545049
6. Chromosome 22q12.1 microdeletions involving the MN1 gene confirm it as a candidate gene for cleft palate. PMID: 25944382
7. genotype-phenotype correlation among our patients and those previously reported with overlapping 22q12 deletions, we identified a 560 kb critical region containing the MN1 gene that is implicated in human cleft palate formation PMID: 25810350
8. these results suggest that deregulated MN1 expression contributes to the pathogenesis of pediatric B-ALL. PMID: 26111797
9. identified potential driver mutations in NF2 (neurofibromatosis type 2) and MN1 (meningioma 1). PMID: 25549701
10. cotransduction of an activated HOX gene (NUP98HOXD13) with MN1 induces a serially transplantable acute myeloid leukemia (AML). PMID: 25339361
11. MN1 overexpression independently predicts bad clinical outcome in CN-AML patients PMID: 23394438
12. High MN1 expression confers worse prognosis in Chinese adult patients with de novo acute myeloid leukemia. PMID: 23515710
13. Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction PMID: 22905229
14. A high MEBE (MN1,ERG, BAALC, EVI1) expression score is an unfavorable prognostic marker in Myelodysplastic syndrome and is associated with an increased risk for progression to Acute myeloid leukemia. PMID: 22488406
15. analysis of genetic variants hints at the contribution of TGFB3 and MN1 in the aetiology of submucous cleft palate PMID: 22409215
16. low MN1 expression confers better prognosis in older CN-AML patients and may refine the European LeukemiaNet classification. Biologic features associated with MN1 expression may help identify new treatment targets. PMID: 21828125
17. MN1-ETV6 fusion gene arising from Myelodysplastic Syndrome with 5q trisomy is associated with acute myeloid leukemia. PMID: 21600651
18. high MN1 levels are important for the growth of leukemic cells, and that increased MN1 expression can synergize with MLL-ENL and probably other transforming fusion genes in leukemia induction. PMID: 20072157
19. MN1 is a 1,25-(OH)2D3-induced vitamin D receptor coactivator that also may have critical roles in modulating osteoblast proliferation. PMID: 15890672
20. MN1-translocation-ETS-leukemia exerts its nonlineage-specific leukemogenic effects by promoting the growth of primitive progenitors and blocking their differentiation PMID: 16081688
21. leukemogenic effect of MN1-ets variant gene 6 L in our knock-in mice is pleiotropic, and the type of secondary mutation determines disease outcome PMID: 16105979
22. Up-regulates Insulin-Like Growth Factor Binding Protein 5 at a specific promoter consensus sequence. PMID: 17242174
23. MN1 is a unique oncogene in hematopoiesis that both promotes proliferation/self-renewal and blocks differentiation, and may become useful as a predictive marker in AML treatment. PMID: 17494859
24. MN1 overexpression is associated with the development of inv(16) acute myeloid leukemia PMID: 17525718
25. role of MN1 in myeloid leukemia [review] PMID: 17698380
26. MN1 and MN1-TEL interfere with the ATRA pathway and this might explain the differentiation block in leukemias in which these genes are involved. PMID: 18632758
27. Data demonstrate that MN1 overexpression correlates with progression from MDS to sAML and therefore might be involved in the pathogenesis of sAML PMID: 19391034
28. MN1 expression independently predicts outcome in cytogenetically normal acute myeloid leukemia PMID: 19451432
29. Down-regulation of CEBPA activity contributes to MN1-modulated proliferation and impaired myeloid differentiation of hematopoietic cells. PMID: 19561324

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HGNC: 7180

OMIM: 156100

KEGG: hsa:4330

STRING: 9606.ENSP00000304956

UniGene: Hs.268515