MPP1 Antibody, Biotin conjugated

Code CSB-PA014758LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MPP1 Polyclonal antibody
Uniprot No.
Target Names
MPP1
Alternative Names
55 kDa erythrocyte membrane protein antibody; AAG 12 antibody; AAG12 antibody; Aging associated gene 12 antibody; DXS552 antibody; DXS552E antibody; EM55_HUMAN antibody; EMP 55 antibody; EMP55 antibody; Erythrocyte membrane protein p55 antibody; Membrane protein antibody; Membrane protein palmitoylated 1 55kDa antibody; Membrane protein palmitoylated 1 antibody; Membrane protein; palmitoylated 1; 55kDa antibody; Migration related gene 1 antibody; MPP 1 antibody; MPP1 antibody; MRG 1 antibody; MRG1 antibody; OTTHUMP00000026054 antibody; OTTHUMP00000196176 antibody; p55 antibody; palmitoylated 1 antibody; Palmitoylated erythrocyte membrane protein antibody; Palmitoylated membrane protein 1 antibody; PEMP antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 55 kDa erythrocyte membrane protein (123-252AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
Gene References into Functions
  1. Data suggest that targeting the ATP binding cassette subfamily C member 4 (ABCC4)-membrane palmitoylated protein 1 (MPP1) protein complex can lead to new therapies to improve treatment outcome of acute myeloid leukemia (AML). PMID: 29146910
  2. A new perspective on the role of MPP1 in erythroid cells suggests that direct MPP1-flotillins interactions could be the major driving-force behind the formation of raft domains in red blood cells. PMID: 28865798
  3. conclusion, the data demonstrates that MPP1 interacts with lipid mixtures in two different model membrane systems. PMID: 28653654
  4. Studies indicate that palmitoylated erythrocyte membrane protein p55 (MPP1) and its palmitoylation play a crucial role in lateral membrane organization in erythroid cells. PMID: 25408337
  5. MPP1 knockdown significantly affects the activation of MAP-kinase signaling. PMID: 23507198
  6. MPP1 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
  7. Results show the NMR-derived structure of the human erythroid p55 PDZ domain and propose a possible interaction mode with the C-terminus of glycophorin C. PMID: 16741958
  8. MPP1 links the Usher protein network and the Crumbs protein complex in the retina PMID: 17584769
  9. p55 binds to two distinct sites within the FERM domain, and the alternatively spliced exon 5 is necessary for the membrane targeting of protein 4.1R in epithelial cells. PMID: 18952129
  10. p55-NF2 protein interaction may play a functional role in the regulation of apico-basal polarity and tumor suppression pathways in non-erythroid cells. PMID: 19144871

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Subcellular Location
Cell membrane; Lipid-anchor. Cell projection, stereocilium.
Protein Families
MAGUK family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 7219

OMIM: 305360

KEGG: hsa:4354

STRING: 9606.ENSP00000358547

UniGene: Hs.496984

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