MPZL1 Antibody, Biotin conjugated

Code CSB-PA014775LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MPZL1 Polyclonal antibody
Uniprot No.
Target Names
MPZL1
Alternative Names
MPZL1; PZR; UNQ849/PRO1787; Myelin protein zero-like protein 1; Protein zero-related
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Myelin protein zero-like protein 1 protein (195-258AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
Gene References into Functions
  1. MPZL1 is a target gene within the 1q24.1-24.2 amplicon that plays a pivotal role in HCC cell migration and tumor metastasis, and a novel MPZL1/Src/cortactin signaling cascade. PMID: 24296779
  2. Clinico-electrophysiological features and MRI findings are described in leg musculature from three patients belonging to a CMT2J pedigree due to MPZ Thr124Met mutation. PMID: 19629567
  3. PZR is a major receptor of ConA and has an important role in cell signaling via c-Src. Considering the various biological activities of ConA, the study of PZR may have major therapeutic implications PMID: 11751924
  4. Characterization of PZR1b, an alternative spliced isoform of PZR. PMID: 12684038
  5. the MPZL1/PZR gene may be important in the predisposition to schizophrenia among Han Chinese PMID: 16702974
  6. Phosphorylation and localization of PZR in cultured endothelial cells is reported. PMID: 18568953

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Myelin P0 protein family
Tissue Specificity
Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appe
Database Links

HGNC: 7226

OMIM: 604376

KEGG: hsa:9019

STRING: 9606.ENSP00000352513

UniGene: Hs.493919

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