MPZL1 Antibody, HRP conjugated

Datasheet

Code	CSB-PA014775LB01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MPZL1 Polyclonal antibody

Uniprot No.

O95297

Target Names

MPZL1

Alternative Names

MPZL1; PZR; UNQ849/PRO1787; Myelin protein zero-like protein 1; Protein zero-related

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Myelin protein zero-like protein 1 protein (195-258AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

Gene References into Functions

MPZL1 is a target gene within the 1q24.1-24.2 amplicon that plays a pivotal role in HCC cell migration and tumor metastasis, and a novel MPZL1/Src/cortactin signaling cascade. PMID: 24296779
Clinico-electrophysiological features and MRI findings are described in leg musculature from three patients belonging to a CMT2J pedigree due to MPZ Thr124Met mutation. PMID: 19629567
PZR is a major receptor of ConA and has an important role in cell signaling via c-Src. Considering the various biological activities of ConA, the study of PZR may have major therapeutic implications PMID: 11751924
Characterization of PZR1b, an alternative spliced isoform of PZR. PMID: 12684038
the MPZL1/PZR gene may be important in the predisposition to schizophrenia among Han Chinese PMID: 16702974
Phosphorylation and localization of PZR in cultured endothelial cells is reported. PMID: 18568953

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Myelin P0 protein family

Tissue Specificity

Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appe

Database Links

HGNC: 7226

OMIM: 604376

KEGG: hsa:9019

STRING: 9606.ENSP00000352513

UniGene: Hs.493919

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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