MRGPRX2 Antibody

Code CSB-PA839361LA01HU
Size US$299
  • Positive WB detected in: MCF-7 whole cell lysate, Hela whole cell lysate, Mouse liver tissue
    All lanes: MRGPRX2 antibody at 1:2000
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 38 kDa
    Observed band size: 38 kDa
  • Immunofluorescent analysis of MCF-7 cells using CSB-PA839361LA01HU at dilution of 1:200 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details

MRGPRX2 polyclonal antibody CSB-PA839361LA01HU was produced in the rabbit immunized by using the Recombinant Human Mas-related G-protein coupled receptor member X2 protein (286-330AA) as the immunogen. The target protein MRGPRX2 is a mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Diseases associated with MRGPRX2 include Ceftazidime Allergy and Cephalosporin Allergy.
This Rabbit anti-Homo sapiens (Human) MRGPRX2 Polyclonal antibody was tested in the ELISA, WB and IF applications. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It reacts with the MRGPRX2 proteins of human or mouse-origin and may be used to detect the endogenous levels of MRGPRX2 protein.
Full Product Name Rabbit anti-Homo sapiens (Human) MRGPRX2 Polyclonal antibody
Uniprot No. Q96LB1
Target Names MRGPRX2
Alternative Names
MRGPRX2; MRGX2; Mas-related G-protein coupled receptor member X2
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Mas-related G-protein coupled receptor member X2 protein (286-330AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The MRGPRX2 Antibody (Product code: CSB-PA839361LA01HU) is Non-conjugated. For MRGPRX2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA839361LB01HU MRGPRX2 Antibody, HRP conjugated ELISA
FITC CSB-PA839361LC01HU MRGPRX2 Antibody, FITC conjugated
Biotin CSB-PA839361LD01HU MRGPRX2 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.
Gene References into Functions
  1. Low levels of MRGPRX2 were detected in non-asthma lung mast cells, but its expression was significantly up-regulated in asthma lung mast cells. PMID: 29295703
  2. the present study demonstrates that FceRI and MRGPRX2 function can be inversely regulated by SCF in an acute scenario, suggesting that the signaling requirements differ profoundly between the routes. PMID: 28859248
  3. The authors discuss the possibility that MRGPRX2 responds to various as-yet-unidentified endogenous ligands that have specific characteristics, and propose that MRGPRX2 plays an important role in regulating inflammatory responses to endogenous harmful stimuli, such as protein breakdown products released from damaged or dying cells. PMID: 29484687
  4. these peptides are identified as fragments of albumin. The isolated fragments activate MRGPRX2 and degranulate MRGPRX2 expressing LAD 2 cells in dose-dependent manner. The isolated basic peptides generated from human albumin are able to degranulate mast cells via the MRGPRX2. PMID: 28844982
  5. The results showed a kind of mechanism that sinomenine-induced anaphylactoid reactions were mediated by MRGPRX2 via activating PLC molecular signaling pathways to provoke mast cells Ca(2+) mobilization and degranulation. PMID: 28987593
  6. data suggest that mast cells play important roles in both gingival homeostasis and periodontal disease by orchestrating an interaction between gingival epithelial cells and neutrophils via MRGPRX2-mediated degranulation PMID: 28694291
  7. MRGX2 is related to nociception, adrenal gland secretion and mast cell degranulation. (Review) PMID: 26106044
  8. contributes to larger and longer lasting wheal reactions to intradermally injected neuropeptides in patients with chronic urticaria PMID: 24954276
  9. Ectopic expression of MrgX2 in rat basophilic leukemia RBL-2H3 cells and murine bone marrow mast cells renders these cells responsive to human beta-defensin for degranulation. PMID: 23698749
  10. identified MrgX2 as a novel G protein-coupled receptor for the antibacterial peptide LL-37 and demonstrated that unlike most G protein-coupled receptors it is resistant to agonist-induced receptor phosphorylation, desensitization, and internalization. PMID: 22069323
  11. cortistatin-14 shown to be a high affinity ligand for G protein coupled receptor MrgX2 which is expressed in dorsal root ganglion PMID: 12915402
  12. MRGX2 amino acid substitutions may alter the interactions between MRGX2 protein and its ligand, thus, potentially led to adaptive changes of the pain-perception-related nervous system during human evolution. PMID: 15862286

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Subcellular Location Cell membrane; Multi-pass membrane protein.
Protein Families G-protein coupled receptor 1 family, Mas subfamily
Tissue Specificity Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion. Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protei
Database Links

HGNC: 17983

OMIM: 607228

KEGG: hsa:117194

STRING: 9606.ENSP00000333800

UniGene: Hs.350566

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