MRM3 Antibody, FITC conjugated

Code CSB-PA867196LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MRM3 Polyclonal antibody
Uniprot No.
Target Names
MRM3
Alternative Names
16S rRNA (guanosine(1370)-2'-O)-methyltransferase antibody; 16S rRNA [Gm1370] 2'-O-methyltransferase antibody; 4833420N02Rik antibody; AI255153 antibody; FLJ10581 antibody; HC90 antibody; MRM3 antibody; MRM3_HUMAN antibody; Putative RNA methyltransferase antibody; RMTL1 antibody; RNA methyltransferase like 1 antibody; RNA methyltransferase like protein 1 antibody; RNA methyltransferase-like protein 1 antibody; RP23-147P4.7 antibody; rRNA methyltransferase 3, mitochondrial antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human rRNA methyltransferase 3, mitochondrial protein (41-205AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Gene References into Functions
  1. MRM2 and MRM3 are human mitochondrial methyltransferases involved in the modification of 16S rRNA and are important factors for the biogenesis and function of the large subunit of the mitochondrial ribosome. PMID: 25009282
  2. Data show that 2'-O-methyltransferases MRM1, MRM2, and RNMTL1 are responsible for modification of large subunit rRNA at residues G1145, U1369, and G1370, respectively. PMID: 25074936
  3. The ATF/CREB site is the key element for transcription of this protein found on human chromosome 17. PMID: 12296377
Subcellular Location
Mitochondrion.
Protein Families
Class IV-like SAM-binding methyltransferase superfamily, RNA methyltransferase TrmH family
Tissue Specificity
Expressed at same level in normal liver and hepatocarcinoma.
Database Links

HGNC: 18485

OMIM: 612600

KEGG: hsa:55178

STRING: 9606.ENSP00000306080

UniGene: Hs.182729

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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