MRPL41 Antibody, FITC conjugated

Code CSB-PA811620LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MRPL41 Polyclonal antibody
Uniprot No.
Target Names
MRPL41
Alternative Names
39S ribosomal protein L27 homolog antibody; 39S ribosomal protein L41 antibody; 39S ribosomal protein L41 mitochondrial antibody; Bcl-2-interacting mitochondrial ribosomal protein L41 antibody; BMRP antibody; Cell proliferation-inducing gene 3 protein antibody; L41mt antibody; mitochondrial antibody; Mitochondrial ribosomal protein L41 antibody; MRP L27 antibody; MRP-L27 homolog antibody; MRP-L41 antibody; MRPL27 antibody; mRpL41 antibody; PIG3 antibody; Proliferation inducing gene 3 antibody; RM41_HUMAN antibody; RPML27 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 39S ribosomal protein L41, mitochondrial protein (14-137AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
Gene References into Functions
  1. Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. PMID: 24160266
  2. Apoptosis-inducing ability of wild-type BMRP is blocked by Bcl-2 through several mechanisms. PMID: 22711503
  3. region of BMRP required for the interaction with Bcl-2 is very relevant for the cell death-inducing activity of the protein PMID: 21253851
  4. BMRP is a mitochondrial ribosomal protein involved in the regulation of cell death by apoptosis, probably affecting pathways mediated by Bcl-2 and caspases. PMID: 15547950
  5. mitochondrial ribosomal protein L41 (MRPL41) is localized in the mitochondria, stabilizes the p53 protein, and enhances its translocation to the mitochondria, thereby inducing apoptosis. PMID: 16024796
  6. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and p27(Kip1) levels under the growth inhibitory conditions. PMID: 16256947

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Subcellular Location
Mitochondrion.
Protein Families
Mitochondrion-specific ribosomal protein mL41 family
Tissue Specificity
Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
Database Links

HGNC: 14492

OMIM: 611846

KEGG: hsa:64975

STRING: 9606.ENSP00000360498

UniGene: Hs.44017

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