Recombinant Human 39S ribosomal protein L41, mitochondrial (MRPL41)

Code CSB-YP811620HU
MSDS
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Source Yeast
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Code CSB-EP811620HU
MSDS
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Source E.coli
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Code CSB-EP811620HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP811620HU
MSDS
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Source Baculovirus
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Code CSB-MP811620HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
MRPL41
Uniprot No.
Alternative Names
39S ribosomal protein L27 homolog; 39S ribosomal protein L41; 39S ribosomal protein L41 mitochondrial; Bcl-2-interacting mitochondrial ribosomal protein L41; BMRP; Cell proliferation-inducing gene 3 protein; L41mt; mitochondrial; Mitochondrial ribosomal protein L41; MRP L27; MRP-L27 homolog; MRP-L41; MRPL27; mRpL41; PIG3; Proliferation inducing gene 3; RM41_HUMAN; RPML27
Species
Homo sapiens (Human)
Expression Region
14-137
Target Protein Sequence
GADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
Gene References into Functions
  1. Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. PMID: 24160266
  2. Apoptosis-inducing ability of wild-type BMRP is blocked by Bcl-2 through several mechanisms. PMID: 22711503
  3. region of BMRP required for the interaction with Bcl-2 is very relevant for the cell death-inducing activity of the protein PMID: 21253851
  4. BMRP is a mitochondrial ribosomal protein involved in the regulation of cell death by apoptosis, probably affecting pathways mediated by Bcl-2 and caspases. PMID: 15547950
  5. mitochondrial ribosomal protein L41 (MRPL41) is localized in the mitochondria, stabilizes the p53 protein, and enhances its translocation to the mitochondria, thereby inducing apoptosis. PMID: 16024796
  6. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and p27(Kip1) levels under the growth inhibitory conditions. PMID: 16256947

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Subcellular Location
Mitochondrion.
Protein Families
Mitochondrion-specific ribosomal protein mL41 family
Tissue Specificity
Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
Database Links

HGNC: 14492

OMIM: 611846

KEGG: hsa:64975

STRING: 9606.ENSP00000360498

UniGene: Hs.44017

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