MSL2 Antibody, HRP conjugated

Code CSB-PA875722LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MSL2 Polyclonal antibody
Uniprot No.
Target Names
MSL2
Alternative Names
Male specific lethal 2 homolog (Drosophila) antibody; Male specific lethal 2 homolog 1 antibody; Male specific lethal 2 homolog antibody; Male specific lethal 2 like 1 antibody; Male-specific lethal 2 homolog antibody; Male-specific lethal 2-like 1 antibody; Male-specific lethal-2 homolog 1 antibody; MSL-2 antibody; MSL2 antibody; MSL2-like 1 antibody; MSL2_HUMAN antibody; MSL2L1 antibody; Ring finger protein 184 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase MSL2 protein (341-473AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Gene References into Functions
  1. HBx-elevated MSL2 modulates hepatitis B virus (HBV) cccDNA in hepatoma cells to promote hepatocarcinogenesis, forming a positive feedback loop of HBx/MSL2/cccDNA/HBV. PMID: 28608964
  2. Msl2 is a novel component of the vertebrate DNA damage response. PMID: 23874665
  3. MSL2, together with MSL1, has robust histone ubiquitylation activity that mainly targets nucleosomal H2B on lysine 34. PMID: 21726816
  4. A multisubunit human histone acetylase complex that contains homologs of the Drosophila MSL proteins MOF, MSL1 (hampin A), MSL2, and MSL3 was described. This complex is responsible for histone H4 lysine-16 acetylation of all cellular chromosomes. PMID: 16227571
Protein Families
MSL2 family
Database Links

HGNC: 25544

OMIM: 614802

KEGG: hsa:55167

STRING: 9606.ENSP00000311827

UniGene: Hs.18631

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