MSL2 Antibody

Datasheet
Code CSB-PA875722LA01HU
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Size US$299
Uniprot No. Q9HCI7
Image
  • Western Blot
    Positive WB detected in: U251 whole cell lysate
    All lanes: MSL2 antibody at 5µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 63, 55 kDa
    Observed band size: 63 kDa

Immunogen Recombinant Human E3 ubiquitin-protein ligase MSL2 protein (341-473AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB; Recommended dilution: WB:1:500-1:5000
Relevance Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.-) (E3 ubiquitin-protein transferase MSL2) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184), MSL2, KIAA1585 MSL2L1 RNF184
Immunogen Species Human
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names MSL2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Protein Families MSL2 family
Database Links

HGNC: 25544

OMIM: 614802

KEGG: hsa:55167

STRING: 9606.ENSP00000311827

UniGene: Hs.18631

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