MSRB3 Antibody

1. we characterise the mammalian enzyme Msr B3. There are two splice variants of this enzyme that differ only in their N-terminal signal sequence, which directs the protein to either the endoplasmic reticulum (ER) or mitochondria PMID: 29420254
2. This characterization of GWAS-implicated MSRB3 protein expression in human hippocampus suggests that patterns of neuronal and vascular MsrB3 protein expression reflect or underlie pathology associated with Alzheimer disease. PMID: 28777754
3. Oncogene induction in differentiated cells induces massive DNA damage, mammary stem cells are resistant, owing to a preemptive program driven by ZEB1 and MSRB3. The prevention of oncogene-induced DNA damage precludes induction of the oncosuppressive p53-dependent DNA-damage response, thereby increasing stem cells' intrinsic susceptibility to malignant transformation. PMID: 28394329
4. The data suggest that MsrB3 attenuates HO-1 induction by inhibiting reactive oxygen species production, endoplasmic reticulum stress, and Nrf2 activation. PMID: 27059143
5. MsrB3 plays an important role in cancer cell survival through the modulation of the intrinsic apoptosis pathway. PMID: 28007593
6. Taken together, our results suggest that MsrB3 plays a critical role in cancer cell apoptosis through the modulation of ER stress status. PMID: 28389299
7. MsrB3 deficiency activates the cell cycle inhibitors p21 and p27. PMID: 24583268
8. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. PMID: 22422452
9. these data provide evidence that the ER-type of MsrB3 plays an important role in protection against ER stress, suggesting that MsrB3 may be involved in the regulation of ER homeostasis. PMID: 22405767
10. Taken together, these data provide evidence that the ER type of MsrB, MsrB3A, plays an important role in protection mechanisms against oxidative, cold and heat stresses and, moreover, in the regulation of fruit fly aging. PMID: 22310715
11. Results identified an antimicrobial peptide from the human methionine sulfoxide reductase B3 protein. PMID: 22027001
12. an in vitro assay revealed that p.Cys89Gly completely abolished MSRB3 enzymatic activity and that p.Arg19X is a null allele for MSRB3 mitochondrial isoforms, indicating that DFNB74 deafness might be a mitochondrial disease limited to the inner ear. PMID: 21185009
13. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195514

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HGNC: 27375

OMIM: 613718

KEGG: hsa:253827

STRING: 9606.ENSP00000347324

UniGene: Hs.339024