MT-CYB Antibody

Code CSB-PA581286
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA581286(MT-CYB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA581286(MT-CYB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
Alternative Names
COB antibody; Complex III subunit 3 antibody; Complex III subunit III antibody; CYB_HUMAN antibody; CYTB antibody; Cytochrome b antibody; Cytochrome b c1 complex subunit 3 antibody; Cytochrome b-c1 complex subunit 3 antibody; Mitochondrially encoded cytochrome b antibody; MT-CYB antibody; MTCYB antibody; Ubiquinol cytochrome c reductase complex cytochrome b subunit antibody; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human MT-CYB
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Gene References into Functions
  1. The heteroplasmy level of some mutations in gene MT-CYB among women with asymptomatic atherosclerosis PMID: 29368910
  2. The effects of mutation in mitochondrially encoded cytochrome b are reviewed. PMID: 28132468
  3. Mitochondrial mutation m.15804T>C in the mtCYB gene in a family with fibromyalgia is associated with NLRP3-inflammasome activation. PMID: 26566881
  4. These results indicate that miR-151a-5p may participate in the regulation of cellular respiration and ATP production through targeting Cytb. PMID: 26626315
  5. The polymorphisms of CYTB as a very useful DNA marker were significantly different between different geographical Uyghur PMID: 24103151
  6. Significant elevation of ERalpha and MTCYB transcript levels in premenopausal leiomyomas and its association with ERalpha, -397 CC genotype suggests the mitochondrial-mediated role of estrogen as the promoter of leiomyoma tumorigenesis. PMID: 21506659
  7. mitocryptide-2 (MCT-2) and its human homolog hMCT-2 are cryptides that activate neutrophils PMID: 19342687
  8. The other proband had a non-synonymous G15221A mutation in the cytochrome b gene. PMID: 12031626
  9. In a mitochondrial myopathy patient, a novel stop-codon mutation (G15761A) was found in the mitochondrial DNA (mtDNA)-encoded cytochrome b gene, resulting in loss of the last 41 amino acids of the protein and complex III deficiency PMID: 12686403
  10. clinical/phenotypic variability of the G15498A mutation in mitochondrial DNA PMID: 14735157
  11. biochemical and molecular genetic studies of a patient with both muscle and brain involvement and a severe reduction in the activities of both complexes I and III in skeletal muscle due to a novel mutation in the MTCYB gene PMID: 16008558
  12. caspase 8-dependent cleavage of mitochondrial Cyt b and translocation of its C-terminal half into the cytoplasm occurred during FAS-induced apoptosis in both chicken and human cells PMID: 18796602
  13. CytbI7T has a role in longevity related to caloric restriction PMID: 19503808
  14. The m.15635T>C transition (S297P) was carried by a newborn who presented with a polyvisceral failure. PMID: 19563916
  15. cytochrome B gene mutation induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells. PMID: 19569044

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Involvement in disease
Cardiomyopathy, infantile histiocytoid (CMIH); Leber hereditary optic neuropathy (LHON)
Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
Cytochrome b family
Database Links

HGNC: 7427

OMIM: 500000

KEGG: hsa:4519

STRING: 9606.ENSP00000354554

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