MT1F Antibody, Biotin conjugated

Code CSB-PA17409D0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MT1F Polyclonal antibody
Uniprot No.
Target Names
MT1F
Alternative Names
MT1F antibody; PRO0376 antibody; Metallothionein-1F antibody; MT-1F antibody; Metallothionein-IF antibody; MT-IF antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Metallothionein-1F protein (1-61AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Gene References into Functions
  1. we found that metallothionein expression induced by Cd occurred much later, with the expression seen at least 12h or more after the Nrf2-dependent immediate responses were almost completed. PMID: 24440467
  2. Metallothionein may have a role in the control of apoptosis in pleomorphic adenoma. PMID: 23332881
  3. Aortic protection in diabetes by zinc supplementation is associated with upregulation of both metallothionein and Nrf2 expression. PMID: 23536959
  4. findings show 5 MT isoforms were overexpressed in non-small cell lung cancer and overexpression of MT-1F and MT-2A predicted poor outcome; both isoforms may be involved in progression of this cancer type; upregulated MT-1F expression associated with larger primary tumor size and higher grade of malignanacy PMID: 23064051
  5. MT1F is a putative tumor suppressor gene in colon carcinogenesis that is downregulated mainly by loss of heterozygosity in colon cancer tissue PMID: 22426038
  6. This study identifies for the first time the relevant metallothionein isoforms for colorectal cancer progression. PMID: 21820154
  7. Studies provide the mechanistic properties of metal binding for metallothionein metallation. PMID: 21409206
  8. MT-1 rs8052394 A allele is associated with oral squamous cell carcinoma. PMID: 21128001
  9. In the liver cancer tissue, MT1F shows down-regulated expression that supports the inhibited function of MT1F in cancer growth PMID: 15369632
  10. Knockdown of MT1F gene increased particular matter(2.5)-induced H2O2 release in alveolar macrophages. PMID: 19251948

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Protein Families
Metallothionein superfamily, Type 1 family
Database Links

HGNC: 7398

OMIM: 156352

KEGG: hsa:4494

STRING: 9606.ENSP00000334872

UniGene: Hs.513626

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