Recombinant Human Metallothionein-1F(MT1F),partial

Code CSB-YP015112HU
Size US$1298Purchase it in Cusabio online store
(only available for customers from the US)
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names MT1F
Uniprot No. P04733
Research Area Cancer
Alternative Names MT1F; PRO0376; Metallothionein-1F; MT-1F; Metallothionein-IF; MT-IF
Species Homo sapiens (Human)
Source Yeast
Expression Region 1-59aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 7.9kDa
Protein Length Partial
Tag Info N-terminal 6xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Data

Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Gene References into Functions
  1. we found that metallothionein expression induced by Cd occurred much later, with the expression seen at least 12h or more after the Nrf2-dependent immediate responses were almost completed. PMID: 24440467
  2. Metallothionein may have a role in the control of apoptosis in pleomorphic adenoma. PMID: 23332881
  3. Aortic protection in diabetes by zinc supplementation is associated with upregulation of both metallothionein and Nrf2 expression. PMID: 23536959
  4. findings show 5 MT isoforms were overexpressed in non-small cell lung cancer and overexpression of MT-1F and MT-2A predicted poor outcome; both isoforms may be involved in progression of this cancer type; upregulated MT-1F expression associated with larger primary tumor size and higher grade of malignanacy PMID: 23064051
  5. MT1F is a putative tumor suppressor gene in colon carcinogenesis that is downregulated mainly by loss of heterozygosity in colon cancer tissue PMID: 22426038
  6. This study identifies for the first time the relevant metallothionein isoforms for colorectal cancer progression. PMID: 21820154
  7. Studies provide the mechanistic properties of metal binding for metallothionein metallation. PMID: 21409206
  8. MT-1 rs8052394 A allele is associated with oral squamous cell carcinoma. PMID: 21128001
  9. In the liver cancer tissue, MT1F shows down-regulated expression that supports the inhibited function of MT1F in cancer growth PMID: 15369632
  10. Knockdown of MT1F gene increased particular matter(2.5)-induced H2O2 release in alveolar macrophages. PMID: 19251948

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Protein Families Metallothionein superfamily, Type 1 family
Database Links

HGNC: 7398

OMIM: 156352

KEGG: hsa:4494

STRING: 9606.ENSP00000334872

UniGene: Hs.513626


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