MTA3 Antibody

Code CSB-PA015127GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
1110002J22Rik antibody; fj99h01 antibody; KIAA1266 antibody; Metastasis associated 1 family, member 3 antibody; Metastasis associated 3 antibody; Metastasis associated family, member 3 antibody; Metastasis associated gene 3 antibody; Metastasis associated gene family, member 3 antibody; Metastasis associated protein MTA3 antibody; Metastasis-associated protein MTA3 antibody; MGC56396 antibody; MGC77410 antibody; mKIAA1266 antibody; mta1 antibody; Mta3 antibody; MTA3 metastasis associated 1 family, member 3 antibody; Mta3 metastasis associated 3 antibody; MTA3_HUMAN antibody; wu:fj99h01 antibody; zgc:56396 antibody
Raised in
Species Reactivity
Human MTA3
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Applications : WB

Review: Western blot analysis of MAT3 and LBR in BHK cells infected with Eimeria tenella compared with mock-infected cells.

By Anonymous

Target Background

Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
Gene References into Functions
  1. Results show that metastasis associated 1 family member 3 (MTA3) level was decreased in colorectal cancer and significantly correlated with tumor cell invasion and metastasis, and that MTA3 might serve as a potential marker of tumor recurrence and prognosis of colorectal cancer. PMID: 28418887
  2. MTA3 is an oncogene of HCC, predicts poor prognosis of HCC, and may be a future marker of HCC treatment. PMID: 27992674
  3. As a master regulator, MTA3 governs the target selection for nucleosome remodeling and histone deacetylation and functions as a transcriptional repressor. MTA3 dysregulation is associated with tumor progression, invasion, and metastasis in various cancers. MTA is also a key regulator of E-cadherin expression and epithelial-to-mesenchymal transition. PMID: 28279208
  4. MTA3 depletion induced cell cycle arrest at the G1/S boundary. Western blotting analysis revealed that the knockdown of MTA3 decreased the protein levels of cyclin A, cyclin D1 and p-Rb. These results indicate that MTA3 plays an important role in NSCLC progression PMID: 23840517
  5. Our results demonstrated that MTA3 overexpression contributes to colorectal cancer carcinogenesis, progression, and chemoresistance. MTA3 could serve as a potential therapeutic target in colorectal cancer PMID: 28351306
  6. Studies indicate that metastasis associated family, member 3 protein (MTA3) is expressed in various tissues and is associated with different physiological functions, and appears to play more complicated roles in cancers. PMID: 27033852
  7. role in terminal trophoblast differentiation PMID: 26198267
  8. MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression. PMID: 26483332
  9. This review focuses on the current knowledge about the function and regulation of MTA1 and MTA3 proteins in gynecological cancer, including ovarian, endometrial, and cervical tumors. PMID: 25319202
  10. MAT3 over-expression in non-small cell lung carcinoma and MAT3 mRNA level is a risk factor for lymph node metastasis and survival. PMID: 24107548
  11. Using western blotting and luciferase assays, MTA3 was identified as a target of miR-495 PMID: 24293376
  12. MTA3 expression is an independent prognostic factor in patients with gastroesophageal junction adenocarcinoma. PMID: 23671646
  13. Down-regulation of MTA3 and up-regulation of CGB5 and Snail are associated with preeclampsia. PMID: 23510993
  14. MTA3 is not a useful marker to assess and identify high-risk patients with endometrial adenocarcinomas PMID: 20865667
  15. The absence of MTA3 leads to aberrant expression of Snail, a master regulator of epithelial to mesenchymal transitions. This results in loss of expression of E-cadherin, causing changes in epithelial architecture and invasive growth. PMID: 12705869
  16. MTA3 does not repress transcription to a significant level and appears to have a diffused pattern of subcellular localization, suggesting a biological role distinct from that of the other two MTA proteins. PMID: 12920132
  17. estrogen receptor-alpha regulates metastatic tumor antigen 3 pathway PMID: 15169784
  18. Molecular dissection of the MTA3 promoter using transient transfection assays identified a composite element required for high-level transcription consisting of an SP1 site in close proximity to a consensus estrogen response element half-site. PMID: 15358836
  19. a cell type-specific subunit of the corepressor complex Mi-2/NuRD,a cofactor for BCL-6-dependent B cell fate determination. PMID: 15454082
  20. These findings identify MTA3 as an upstream physiologic repressor of Wnt4 in mammary epithelial cells. PMID: 17050676
  21. the high expression level of MTA proteins in human chorionic cells might facilitate trophoblast cell migration and neoangiogenesis PMID: 19363681

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Subcellular Location
Tissue Specificity
Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.
Database Links

HGNC: 23784

OMIM: 609050

KEGG: hsa:57504

STRING: 9606.ENSP00000385045

UniGene: Hs.435413

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