MTA3 Antibody

1. Results show that metastasis associated 1 family member 3 (MTA3) level was decreased in colorectal cancer and significantly correlated with tumor cell invasion and metastasis, and that MTA3 might serve as a potential marker of tumor recurrence and prognosis of colorectal cancer. PMID: 28418887
2. MTA3 is an oncogene of HCC, predicts poor prognosis of HCC, and may be a future marker of HCC treatment. PMID: 27992674
3. As a master regulator, MTA3 governs the target selection for nucleosome remodeling and histone deacetylation and functions as a transcriptional repressor. MTA3 dysregulation is associated with tumor progression, invasion, and metastasis in various cancers. MTA is also a key regulator of E-cadherin expression and epithelial-to-mesenchymal transition. PMID: 28279208
4. MTA3 depletion induced cell cycle arrest at the G1/S boundary. Western blotting analysis revealed that the knockdown of MTA3 decreased the protein levels of cyclin A, cyclin D1 and p-Rb. These results indicate that MTA3 plays an important role in NSCLC progression PMID: 23840517
5. Our results demonstrated that MTA3 overexpression contributes to colorectal cancer carcinogenesis, progression, and chemoresistance. MTA3 could serve as a potential therapeutic target in colorectal cancer PMID: 28351306
6. Studies indicate that metastasis associated family, member 3 protein (MTA3) is expressed in various tissues and is associated with different physiological functions, and appears to play more complicated roles in cancers. PMID: 27033852
7. role in terminal trophoblast differentiation PMID: 26198267
8. MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression. PMID: 26483332
9. This review focuses on the current knowledge about the function and regulation of MTA1 and MTA3 proteins in gynecological cancer, including ovarian, endometrial, and cervical tumors. PMID: 25319202
10. MAT3 over-expression in non-small cell lung carcinoma and MAT3 mRNA level is a risk factor for lymph node metastasis and survival. PMID: 24107548
11. Using western blotting and luciferase assays, MTA3 was identified as a target of miR-495 PMID: 24293376
12. MTA3 expression is an independent prognostic factor in patients with gastroesophageal junction adenocarcinoma. PMID: 23671646
13. Down-regulation of MTA3 and up-regulation of CGB5 and Snail are associated with preeclampsia. PMID: 23510993
14. MTA3 is not a useful marker to assess and identify high-risk patients with endometrial adenocarcinomas PMID: 20865667
15. The absence of MTA3 leads to aberrant expression of Snail, a master regulator of epithelial to mesenchymal transitions. This results in loss of expression of E-cadherin, causing changes in epithelial architecture and invasive growth. PMID: 12705869
16. MTA3 does not repress transcription to a significant level and appears to have a diffused pattern of subcellular localization, suggesting a biological role distinct from that of the other two MTA proteins. PMID: 12920132
17. estrogen receptor-alpha regulates metastatic tumor antigen 3 pathway PMID: 15169784
18. Molecular dissection of the MTA3 promoter using transient transfection assays identified a composite element required for high-level transcription consisting of an SP1 site in close proximity to a consensus estrogen response element half-site. PMID: 15358836
19. a cell type-specific subunit of the corepressor complex Mi-2/NuRD,a cofactor for BCL-6-dependent B cell fate determination. PMID: 15454082
20. These findings identify MTA3 as an upstream physiologic repressor of Wnt4 in mammary epithelial cells. PMID: 17050676
21. the high expression level of MTA proteins in human chorionic cells might facilitate trophoblast cell migration and neoangiogenesis PMID: 19363681

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HGNC: 23784

OMIM: 609050

KEGG: hsa:57504

STRING: 9606.ENSP00000385045

UniGene: Hs.435413