MTMR14 Antibody

Code CSB-PA015178GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
C3orf29 antibody; Egg derived tyrosine phosphatase homolog antibody; FLJ11546 antibody; FLJ22405 antibody; FLJ46453 antibody; FLJ90311 antibody; HCV NS5A transactivated protein 4 splice variant A binding protein 1 antibody; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 antibody; hEDTP antibody; hJumpy antibody; jumpy antibody; MTMR 14 antibody; MTMR14 antibody; MTMRE_HUMAN antibody; Myotubularin related protein 14 antibody; Myotubularin-related protein 14 antibody; NS5ATP4ABP1 antibody
Raised in
Species Reactivity
Human MTMR14
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
Gene References into Functions
  1. This study provides the first in vivo evidence for a role of myotubularins, and in particular MTMR14, in the regulation of autophagy. PMID: 20595810
  2. The authors uncovered a key negative regulatory role in autophagy of a phosphatidylinositol 3-phosphate (PI3P) phosphatase Jumpy (MTMR14). PMID: 19590496
  3. Study identified a novel phosphoinositide phosphatase, JUMPY in sporadic cases of centronuclear myopathy; two missense variants that affect the enzymatic function were found PMID: 17008356
  4. C3orf29 encodes hJUMPY, a phosphoinositide 3-phosphate phosphatase that acts on PtdIns3P and PtdIns(3,5)P2. A missense mutation disrupts the catalytic activity in a patient with centronuclear myopathy. PMID: 17008356
Involvement in disease
Myopathy, centronuclear, 1 (CNM1)
Subcellular Location
Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Tissue Specificity
Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
Database Links

HGNC: 26190

OMIM: 160150

KEGG: hsa:64419

STRING: 9606.ENSP00000296003

UniGene: Hs.475382

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