MUC6 Antibody

Code CSB-PA058161
Size US$299 How to order?
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA058161(MUC6 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA058161(MUC6 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No. Q6W4X9
Target Names MUC6
Alternative Names Gastric mucin 6 antibody; Gastric Mucin antibody; Gastric mucin-6 antibody; MUC 6 antibody; MUC-6 antibody; Muc6 antibody; MUC6 Fragment antibody; MUC6 mucin antibody; MUC6 mucin Fragment antibody; MUC6_HUMAN antibody; Mucin 6 antibody; Mucin 6 gastric antibody; Mucin 6 oligomeric mucus/gel forming antibody; Mucin glycoprotein Fragment antibody; Mucin-6 antibody; Secretory mucin MUC6 Fragment antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthetic peptide of Human MUC6
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:5000
IHC 1:25-1:100
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
Gene References into Functions
  1. The expression of MUC5AC, MUC2, and MUC6 mRNA in CagA-transfected AGS cells at an NH concentration of 15 mM was significantly higher than that at 0 mM, and decreased at higher concentrations. H. pylori may affect the expression of MUC5AC, MUC2, MUC5B, and MUC6 in AGS cells via CagA and/or NH, but not E-cadherin. PMID: 29869461
  2. decreased expression of alphaGlcNAc relative to MUC6 occurs early and marks the initiation of tumor progression to pancreatic cancer. PMID: 28685935
  3. In ovarian mucinous tumors, MUC6 expression changes with the progression of benign to borderline and malignant tumours PMID: 25298197
  4. Human TTF2 is a lectin that binds alpha-GlcNAc-capped mucin 6 g with antibiotic activity against Helicobacter pylori. PMID: 25124036
  5. High MUC6 expression is associated with gastric carcinoma. PMID: 23828549
  6. A significant association between short rare MUC6-MS5 alleles (7, 9 repeats) and the occurrence of rectal cancer. PMID: 23054008
  7. No significant association was found with variants in the MUC6 gene and evolution of gastric cancer precursor lesions. PMID: 22402132
  8. It is concluded that the expression pattern of secreted mucins including MUC2 and MUC6 is altered in gastric carcinoma. PMID: 20878553
  9. results suggest that MUC6 may inhibit invasion of tumor cells through the basement membrane of the pancreatic duct and slow the development of infiltrating carcinoma. PMID: 21851820
  10. use of MUC6 to differentiate hyperplastic polyps from sessile serrated adenoma/polyps (SSA/P) or SSA/P with dysplasia in individual cases is not reliable because of a lack of specificity. PMID: 21490447
  11. Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses. PMID: 21193402
  12. Positive immunoreactivity for MUC6 appears to be a complementary marker for malignant transformation of gastric epithelial neoplasia PMID: 20602200
  13. The short rare MUC6-minisatellite5 alleles may be related to cancer development by the regulation of MUC6 expression. PMID: 20506113
  14. MUC6 expression is strongly associated with proximal location of serrated polyps, but only has modest utility as a tissue biomarker for sessile serrated adenoma. PMID: 19855374
  15. Expression of MUC6 in oncocytic/pancreatobiliary-type neoplasms but not in villous/intestinal-type neoplasms supports the presence of a pyloropancreatic pathway distinct from the MUC2/CDX2 expressing intestinal pathway in intraductal papillary neoplasia. PMID: 20139757
  16. Data suggest that MUC6 is expressed in tissues other than stomach and pancreas and that the tandem repeat shows greater variation that previously reported. PMID: 15716126
  17. Our results suggest that MUC6 transcription is regulated by NFkappaB and Sp family members. PMID: 15979574
  18. MUC6-positive tumours were significantly associated with higher frequencies of the gains of 20q13.2, compared with MUC6-negative tumours (71.4 vs 30.0%, P=0.0349). PMID: 16447040
  19. Down-regulation of MUC6 may contribute to malignant transformation of gastric epithelial cells and underlie the molecular bases of growth, invasion, metastasis and differentiation of gastric carcinoma. PMID: 16807756
  20. Short MUC6 alleles are associated with H pylori infection. PMID: 17009402
  21. Downregulation of MUC6 is associated with disease progression to adenocarcinoma of the esophagus PMID: 17401217
  22. Report MUC6 expression/pathological features of adenomatous and foveolar gastric epithelial dysplasia. PMID: 18300795
  23. MUC6 was found to have 100% specificity in distinguishing sessile serrated adenoma from hyperplastic polyp PMID: 18360351
  24. Mucin 6 in seminal plasma may therefore interfere with the sexual transmission of HIV-1 by binding to DC-SIGN. PMID: 19682628

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Subcellular Location Secreted.
Tissue Specificity Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal
Database Links

HGNC: 7517

OMIM: 158374

KEGG: hsa:4588

STRING: 9606.ENSP00000406861

UniGene: Hs.528432

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