Recombinant Human Mucin-6(MUC6) ,partial

Code CSB-YP764959HU
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Source Yeast
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Code CSB-EP764959HU
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Source E.coli
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Code CSB-EP764959HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP764959HU
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Source Baculovirus
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Code CSB-MP764959HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names MUC6
Uniprot No. Q6W4X9
Alternative Names Gastric mucin 6; Gastric Mucin; Gastric mucin-6; MUC 6; MUC-6; Muc6; MUC6 Fragment ; MUC6 mucin ; MUC6 mucin Fragment ; MUC6_HUMAN; Mucin 6; Mucin 6 gastric ; Mucin 6 oligomeric mucus/gel forming ; Mucin glycoprotein Fragment ; Mucin-6; Secretory mucin MUC6 Fragment
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
Gene References into Functions
  1. The expression of MUC5AC, MUC2, and MUC6 mRNA in CagA-transfected AGS cells at an NH concentration of 15 mM was significantly higher than that at 0 mM, and decreased at higher concentrations. H. pylori may affect the expression of MUC5AC, MUC2, MUC5B, and MUC6 in AGS cells via CagA and/or NH, but not E-cadherin. PMID: 29869461
  2. decreased expression of alphaGlcNAc relative to MUC6 occurs early and marks the initiation of tumor progression to pancreatic cancer. PMID: 28685935
  3. In ovarian mucinous tumors, MUC6 expression changes with the progression of benign to borderline and malignant tumours PMID: 25298197
  4. Human TTF2 is a lectin that binds alpha-GlcNAc-capped mucin 6 g with antibiotic activity against Helicobacter pylori. PMID: 25124036
  5. High MUC6 expression is associated with gastric carcinoma. PMID: 23828549
  6. A significant association between short rare MUC6-MS5 alleles (7, 9 repeats) and the occurrence of rectal cancer. PMID: 23054008
  7. No significant association was found with variants in the MUC6 gene and evolution of gastric cancer precursor lesions. PMID: 22402132
  8. It is concluded that the expression pattern of secreted mucins including MUC2 and MUC6 is altered in gastric carcinoma. PMID: 20878553
  9. results suggest that MUC6 may inhibit invasion of tumor cells through the basement membrane of the pancreatic duct and slow the development of infiltrating carcinoma. PMID: 21851820
  10. use of MUC6 to differentiate hyperplastic polyps from sessile serrated adenoma/polyps (SSA/P) or SSA/P with dysplasia in individual cases is not reliable because of a lack of specificity. PMID: 21490447
  11. Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses. PMID: 21193402
  12. Positive immunoreactivity for MUC6 appears to be a complementary marker for malignant transformation of gastric epithelial neoplasia PMID: 20602200
  13. The short rare MUC6-minisatellite5 alleles may be related to cancer development by the regulation of MUC6 expression. PMID: 20506113
  14. MUC6 expression is strongly associated with proximal location of serrated polyps, but only has modest utility as a tissue biomarker for sessile serrated adenoma. PMID: 19855374
  15. Expression of MUC6 in oncocytic/pancreatobiliary-type neoplasms but not in villous/intestinal-type neoplasms supports the presence of a pyloropancreatic pathway distinct from the MUC2/CDX2 expressing intestinal pathway in intraductal papillary neoplasia. PMID: 20139757
  16. Data suggest that MUC6 is expressed in tissues other than stomach and pancreas and that the tandem repeat shows greater variation that previously reported. PMID: 15716126
  17. Our results suggest that MUC6 transcription is regulated by NFkappaB and Sp family members. PMID: 15979574
  18. MUC6-positive tumours were significantly associated with higher frequencies of the gains of 20q13.2, compared with MUC6-negative tumours (71.4 vs 30.0%, P=0.0349). PMID: 16447040
  19. Down-regulation of MUC6 may contribute to malignant transformation of gastric epithelial cells and underlie the molecular bases of growth, invasion, metastasis and differentiation of gastric carcinoma. PMID: 16807756
  20. Short MUC6 alleles are associated with H pylori infection. PMID: 17009402
  21. Downregulation of MUC6 is associated with disease progression to adenocarcinoma of the esophagus PMID: 17401217
  22. Report MUC6 expression/pathological features of adenomatous and foveolar gastric epithelial dysplasia. PMID: 18300795
  23. MUC6 was found to have 100% specificity in distinguishing sessile serrated adenoma from hyperplastic polyp PMID: 18360351
  24. Mucin 6 in seminal plasma may therefore interfere with the sexual transmission of HIV-1 by binding to DC-SIGN. PMID: 19682628

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Subcellular Location Secreted.
Tissue Specificity Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal
Database Links

HGNC: 7517

OMIM: 158374

KEGG: hsa:4588

STRING: 9606.ENSP00000406861

UniGene: Hs.528432

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