MYO18B Antibody

Datasheet
Code CSB-PA142898
Former Code(s) CSB-PA278900
Size US$299
Uniprot No. Q8IUG5
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA142898(MYO18B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA142898(MYO18B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
Immunogen Synthetic peptide of Human MYO18B
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,IHC;ELISA:1:1000-1:2000,IHC:1:25-1:100
Relevance The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias myosin XVIIIB
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Target Names MYO18B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Involvement in disease Klippel-Feil syndrome 4, autosomal recessive, with nemaline myopathy and facial dysmorphism (KFS4)
Subcellular Location Cytoplasm, Nucleus, Cytoplasm, myofibril, sarcomere
Protein Families TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Tissue Specificity Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.
Database Links

HGNC: 18150

OMIM: 607295

KEGG: hsa:84700

STRING: 9606.ENSP00000334563

UniGene: Hs.417959

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