MYOZ2 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA873609LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MYOZ2 Polyclonal antibody

Uniprot No.

Q9NPC6

Target Names

MYOZ2

Alternative Names

C4orf5 antibody; Calcineurin binding protein calsarcin 1 antibody; Calsarcin 1 antibody; Calsarcin-1 antibody; Calsarcin1 antibody; CMH16 antibody; CS 1 antibody; CS1 antibody; FATZ related protein 2 antibody; FATZ-related protein 2 antibody; Muscle specific protein antibody; MYOZ 2 antibody; MYOZ2 antibody; MYOZ2_HUMAN antibody; Myozenin-2 antibody; Myozenin2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Myozenin-2 protein (90-180AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Gene References into Functions

may play a modifying role in hypertrophic cardiomyopathy by affecting the penetrance or degree of performance of the MYH7 gene PMID: 28296734
The cardiac phenotype in hypertrophic cardiomyopathy caused by MYOZ2 mutations might be independent of calcineurin activity in the heart. PMID: 22987565
Two missense mutations, S48P substitution and I246M affecting highly conserved amino acids were linked to hereditary Hypertrophic cardiomyopathy characterized by early onset of symptoms, pronounced cardiac hypertrophy, and cardiac arrhythmias. PMID: 17347475
Mutations in MYOZ1 and MYOZ2 are at least very rare events as an underlying disease mechanism for idiopathic or familial DCM PMID: 17434779
Observational study of genotype prevalence. (HuGE Navigator) PMID: 17347475

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Involvement in disease

Cardiomyopathy, familial hypertrophic 16 (CMH16)

Subcellular Location

Cytoplasm, myofibril, sarcomere, Z line.

Protein Families

Myozenin family

Tissue Specificity

Expressed specifically in heart and skeletal muscle.

Database Links

HGNC: 1330

OMIM: 605602

KEGG: hsa:51778

STRING: 9606.ENSP00000306997

UniGene: Hs.732122

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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