MZB1 Antibody

Datasheet

Code	CSB-PA893286
Size	US$100
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Image	Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200 Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200
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Product Details
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Target Background

Product Details

Uniprot No.

Q8WU39

Target Names

MZB1

Alternative Names

MZB1 antibody; Caspase 2 binding protein antibody; FLJ32987 antibody; HSPC190 antibody; Marginal zone B and B1 cell specific protein antibody; Marginal zone B- and B1-cell-specific protein antibody; MEDA 7 antibody; MEDA-7 antibody; Mesenteric estrogen dependent adipose 7 antibody; Mesenteric estrogen-dependent adipose 7 antibody; Mesenteric oestrogen dependent adipose gene 7 antibody; MGC29506 antibody; Mzb1 antibody; MZB1_HUMAN antibody; PACAP antibody; pERp1 antibody; Plasma cell-induced ER protein 1 antibody; Plasma cell-induced resident endoplasmic reticulum protein antibody; Plasma cell-induced resident ER protein antibody; Proapoptotic caspase adapter protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide from Human protein at AA range: 1-50

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Purification Method

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Form

Liquid

Tested Applications

IHC,ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-300
ELISA	1:10000-20000

Protocols

Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.; Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.

Gene References into Functions

expression was positively correlated with a high accumulation of CD8(+) tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma after neoadjuvant chemoradiotherapy PMID: 29180208
Low MZB1 expression was an independent prognostic factor for recurrence after curative gastrectomy and was associated significantly with increased hematogenous recurrence. MZB1 acts as a suppressor of GC. Low MZB1 expression in the primary GC tissue is predictive of recurrence after curative resection. PMID: 27459504
High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature. PMID: 23189934
miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1. PMID: 24014023
results suggested that MGC29506 has the potential of functioning as a novel suppressor gene in gastric cancer PMID: 23434460
methylation-mediated silencing of MZB1 expression leads to loss of its tumor-suppressive activity, which may be a factor in hepatocarcinogenesis PMID: 22573353
Data show that proapoptotic caspase adapter protein PACAP is a potential serum marker of non-small cell lung cancer. PMID: 22613335
MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, was found to encode secreted-type protein with six conserved cysteine residues [MGC29506] PMID: 12792799

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Subcellular Location

[Isoform 1]: Endoplasmic reticulum lumen. Secreted.; [Isoform 2]: Cytoplasm. Note=Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).

Protein Families

MZB1 family

Tissue Specificity

Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.

Database Links

HGNC: 30125

OMIM: 609447

KEGG: hsa:51237

STRING: 9606.ENSP00000303920

UniGene: Hs.409563

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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