Mgll Antibody, Biotin conjugated

Code CSB-PA013787LD01RA
Size US$166
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Mgll Polyclonal antibody
Uniprot No.
Target Names
Mgll
Alternative Names
Mgll antibody; Mgl2 antibody; Monoglyceride lipase antibody; MGL antibody; EC 3.1.1.23 antibody; Monoacylglycerol lipase antibody; MAGL antibody
Raised in
Rabbit
Species Reactivity
Rat
Immunogen
Recombinant Rat Monoglyceride lipase protein (1-303AA)
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
Gene References into Functions
  1. 4 weeks of post-weaning social isolation increased aggressive grooming of a novel same-sex conspecific in male and female rats. Treatment with the MAGL inhibitor MJN110 eliminated this increase in aggressive grooming in both males and females, without reducing non-aggressive social behavior. Activation of the medial prefrontal cortex was increased by social interaction but was blunted by MJN110 only in females. PMID: 29292159
  2. MGL has an important role in insulin secretion PMID: 26867016
  3. expression of MAGL is distributed in certain cell types and time-dependently expressed in skeletal muscles after trauma, suggesting that MAGL may be involved in inflammatory response, fibrogenesis and regeneration during skeletal muscle wound healing PMID: 25921063
  4. MAGL inhibitor JZL184 is able to inhibit the inflammatory response and interfere with contused muscle healing. PMID: 25912803
  5. results suggest that MAGL regulates phagocytosis, but not LPS-mediated cytokine induction in microglia PMID: 26166819
  6. the current findings support the therapeutic potential of FAAH and monoacylglycerol lipase inhibitors as a novel pharmacotherapy for pain PMID: 25041240
  7. Data indicate that nerve growth factor (NGF) controls monoacylglycerol lipase (MGL) degradation in vitro and in vivo. PMID: 23319656
  8. Pretreatment with MAGL inhibitor URB602 significantly reduces neonatal hypoxic-ischemic brain damage and improves functional outcome. PMID: 22821058
  9. Maternal deprivation induced a significant decrease in MAGL immunoreactivity in the rat hippocampal CA3 and CA1 areas, more marked in males than in females. PMID: 20599824
  10. hydrolysis by means of monoglyceride lipase is a primary mechanism for 2-arachidonoylglycerol inactivation in intact neurons PMID: 12136125
  11. MGL is localized in the enteric nervous system where endocannabinoids regulate intestinal motility. MGL is highly expressed in the epithelium, where this enzyme may have digestive or other functions yet to be determined. PMID: 18948437

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Subcellular Location
Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Protein Families
AB hydrolase superfamily, Monoacylglycerol lipase family
Tissue Specificity
Ubiquitous. Highly expressed in adipose tissue, adrenal gland, ovary, heart, spleen, lung, skeletal muscle, kidney and testis. Highly expressed throughout the brain.
Database Links
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