Mybpc3 Antibody

Code CSB-PA015267YA01RA
Size US$166
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Mybpc3 Polyclonal antibody
Uniprot No.
Target Names
Mybpc3
Alternative Names
Mybpc3 antibody; Myosin-binding protein C antibody; cardiac-type antibody; Cardiac MyBP-C antibody; C-protein antibody; cardiac muscle isoform antibody
Raised in
Rabbit
Species Reactivity
Rat
Immunogen
Recombinant Rat Myosin-binding protein C, cardiac-type protein (645-864AA)
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated

The Mybpc3 Antibody (Product code: CSB-PA015267YA01RA) is Non-conjugated. For Mybpc3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA015267YB01RA Mybpc3 Antibody, HRP conjugated ELISA
FITC CSB-PA015267YC01RA Mybpc3 Antibody, FITC conjugated
Biotin CSB-PA015267YD01RA Mybpc3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Gene References into Functions
  1. Data show that expression of mutant protein cMyBP-C (cMyBP-C(C10mut)) in cultured adult rat cardiomyocytes led to improper localization and contractile dysfunction. PMID: 25583989
  2. These results show that the N-terminal region of MyBP-C stabilizes the ON state of thin filaments and the OFF state of thick filaments and lead to a novel hypothesis for the physiological role of MyBP-C in the regulation of cardiac contractility. PMID: 25512492
  3. Expression of an actin binding-deficient cMyBP-C resulted in abnormal cytosolic distribution of the protein, indicating that interaction with actin is essential for the formation and/or maintenance of normal cMyBP-C sarcomeric distribution. PMID: 22982234
  4. N' region of cMyBP-C is toxic to cardiomyocytes and able to induce cell death. PMID: 22527638
  5. this study suggests that cMyBP-C is an easily releasable myofilament protein that is dephosphorylated, degraded and released into the circulation post-MI. PMID: 21971072

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Protein Families
Immunoglobulin superfamily, MyBP family
Database Links
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