NAAA Antibody, HRP conjugated

Code CSB-PA22919B0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NAAA Polyclonal antibody
Uniprot No.
Target Names
NAAA
Alternative Names
Acid ceramidase like protein antibody; Acid ceramidase-like protein antibody; ASAH like protein antibody; ASAH-like protein antibody; N acylethanolamine acid amidase antibody; N acylethanolamine hydrolyzing acid amidase antibody; N acylsphingosine amidohydrolase (acid ceramidase) like antibody; N acylsphingosine amidohydrolase like antibody; N acylsphingosine amidohydrolase like protein antibody; N-acylethanolamine-hydrolyzing acid amidase subunit beta antibody; N-acylsphingosine amidohydrolase-like antibody; Naaa antibody; NAAA_HUMAN antibody; PLT antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human N-acylethanolamine-hydrolyzing acid amidase protein (29-199AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.
Gene References into Functions
  1. Variants a1 and a2 encoded the same full-length NAAA protein. PMID: 27693242
  2. The results suggest that N-acylethanolamine acid amidase and protein tyrosine kinase 7 may be used as potential tissue biomarkers to avoid overtreatment of non-aggressive prostate cancer PMID: 24741114
  3. MALDI-TOF MS analysis of the human NAAA zymogen (47.7 kDa) treated with peptide-N-glycosidase F (PNGase F) identified 4 glycosylation sites, and acid cleavage of the zymogen into alpha- and beta-subunits (14.6 and 33.3 kDa) activated the enzyme. PMID: 22040171
  4. The level and activity of acid ceramidase in Alzheimer disease (AD) brain may play a role in controlling neuronal apoptosis and may mediate signalling pathways involved in the molecular mechanism of AD. PMID: 15610181
  5. Asn-37, Asn-107, Asn-309, and Asn-333 are actual N-glycosylation sites. The glycosylation appeared to play an important role in stabilizing the enzyme protein. PMID: 17980170
  6. we describe the overexpression and processing of recombinant human acid ceramidase in insect cells, its purification and characterization PMID: 18020949
  7. These results showed that both N-acylethanolamine-hydrolysing acid amidase and fatty acid amide hydrolase are functionally active in human prostate cancer cells. PMID: 18806270

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Subcellular Location
Lysosome. Membrane; Peripheral membrane protein.
Protein Families
Acid ceramidase family
Tissue Specificity
Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.
Database Links

HGNC: 736

OMIM: 607469

KEGG: hsa:27163

STRING: 9606.ENSP00000286733

UniGene: Hs.437365

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