NANS Antibody, HRP conjugated

Code CSB-PA885699LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NANS Polyclonal antibody
Uniprot No.
Target Names
NANS
Alternative Names
EC 2.5.1.56 antibody; EC 2.5.1.57 antibody; N acetylneuraminate 9 phosphate synthase antibody; N acetylneuraminate synthase antibody; N acetylneuraminic acid phosphate synthase antibody; N acetylneuraminic acid synthase antibody; N-acetylneuraminate synthase antibody; N-acetylneuraminate-9-phosphate synthase antibody; N-acetylneuraminic acid phosphate synthase antibody; N-acetylneuraminic acid synthase antibody; NANS antibody; OTTHUMP00000021769 antibody; SAS antibody; Sialic acid phosphate synthase antibody; Sialic acid synthase antibody; SIAS_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sialic acid synthase protein (132-259AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
Gene References into Functions
  1. NANS deficiency is associated with defect in brain and skeletal development. PMID: 27213289
  2. sialic acid synthases kinetics and preliminary mutagenesis experiments reveal the importance of C-terminal antifreeze protein domain PMID: 16274664
  3. The structure of the C-terminal antifreeze-like domain of human sialic acid synthase was determined. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins. PMID: 16597820
Involvement in disease
Spondyloepimetaphyseal dysplasia, Genevieve type (SEMDG)
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 19237

OMIM: 605202

KEGG: hsa:54187

STRING: 9606.ENSP00000210444

UniGene: Hs.522310

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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