NANS Antibody

Code CSB-PA015440GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
NANS
Alternative Names
EC 2.5.1.56 antibody; EC 2.5.1.57 antibody; N acetylneuraminate 9 phosphate synthase antibody; N acetylneuraminate synthase antibody; N acetylneuraminic acid phosphate synthase antibody; N acetylneuraminic acid synthase antibody; N-acetylneuraminate synthase antibody; N-acetylneuraminate-9-phosphate synthase antibody; N-acetylneuraminic acid phosphate synthase antibody; N-acetylneuraminic acid synthase antibody; NANS antibody; OTTHUMP00000021769 antibody; SAS antibody; Sialic acid phosphate synthase antibody; Sialic acid synthase antibody; SIAS_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human NANS
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
Gene References into Functions
  1. NANS deficiency is associated with defect in brain and skeletal development. PMID: 27213289
  2. sialic acid synthases kinetics and preliminary mutagenesis experiments reveal the importance of C-terminal antifreeze protein domain PMID: 16274664
  3. The structure of the C-terminal antifreeze-like domain of human sialic acid synthase was determined. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins. PMID: 16597820
Involvement in disease
Spondyloepimetaphyseal dysplasia, Genevieve type (SEMDG)
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 19237

OMIM: 605202

KEGG: hsa:54187

STRING: 9606.ENSP00000210444

UniGene: Hs.522310

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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