NAPEPLD Antibody, HRP conjugated

Datasheet

Code	CSB-PA764247LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NAPEPLD Polyclonal antibody

Uniprot No.

Q6IQ20

Target Names

NAPEPLD

Alternative Names

C7orf18 antibody; DKFZp781D1098 antibody; FMP30 antibody; Mbldc1 antibody; N acyl phosphatidylethanolamine hydrolyzing phospholipase D antibody; N acyl phosphatidylethanolamine phospholipase D antibody; N-acyl phosphatidylethanolamine phospholipase D antibody; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D antibody; NAPE hydrolyzing phospholipase D antibody; NAPE-hydrolyzing phospholipase D antibody; NAPE-PLD antibody; NAPEP_HUMAN antibody; NAPEPLD antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D protein (1-200AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs.

Gene References into Functions

The AC genotype and C allele of NAPE-PLD rs12540583 locus are risk factors for schizophrenia. PMID: 29652995
NAPE-PLD forms homodimers partly separated by an internal channel and uniquely adapted to associate with phospholipids. PMID: 25684574
our results do not support a clear role of FAAH, CNR1 and NAPE-PLD in BD and lithium response. PMID: 24126189
a major physiological role of NAPE-PLD PMID: 24018423
The differential expression of NAPE-PLD and FAAH suggests that Anandamide could play an important role in the pathophysiology of preeclampsia. PMID: 23122699
NAPE-PLD expression increase steadily after infancy, peaking in adulthood. PMID: 22827915
The results of this study suggested that NAPEPLD was alterated in multip;e sclerosis. PMID: 21251115
a common haplotype in NAPEPLD, an enzyme involved in endocannabinoid synthesis, was protective against obesity. PMID: 20885390
Observational study of gene-disease association. (HuGE Navigator) PMID: 20885390
During the menstrual cycle, NAPE-PLD immunoreactivity was down-regulated in the secretory epithelial gland compared to the proliferative epithelial gland and unaffected in the stroma. PMID: 20369362
The human NAPE-PLD was activated by phosphatidylethanolamine and inhibited by the beta-lactamase substrate nitrocefin. PMID: 19715685

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Subcellular Location

Golgi apparatus membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Nucleus envelope. Nucleus, nucleoplasm.

Protein Families

NAPE-PLD family

Tissue Specificity

Widely expressed. Highest expression in brain, kidney and testis (at protein level). Expressed in adipose tissue (at protein level).

Database Links

HGNC: 21683

OMIM: 612334

KEGG: hsa:222236

STRING: 9606.ENSP00000340093

UniGene: Hs.324271

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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