NCAPD3 Antibody

Datasheet

Code	CSB-PA015515GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P42695

Target Names

NCAPD3

Alternative Names

CAP D3 antibody; CAPD 3 antibody; CAPD3 antibody; CNDD3_HUMAN antibody; Condensin II complex subunit D3 antibody; Condensin-2 complex subunit D3 antibody; FLJ42888 antibody; hCAP-D3 antibody; Hcp 6 antibody; Hcp6 antibody; hHCP 6 antibody; hHCP6 antibody; KIAA0056 antibody; MGC104671 antibody; NCAPD 3 antibody; Ncapd3 antibody; Non SMC condensin II complex subunit D3 antibody; Non-SMC condensin II complex subunit D3 antibody; OTTHUMP00000235403 antibody; OTTHUMP00000235404 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Human NCAPD3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.

Gene References into Functions

Condensin II(CAP-D3 and CAP-H2) and GAIT subunits associate with L1 RNA in a co-dependent manner, independent of IFN-gamma. These findings suggest that cooperation between the Condensin II and GAIT complexes may facilitate a novel mechanism of L1 repression, thus contributing to the maintenance of genome stability in somatic cells PMID: 29028794
CAP-D3 down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells. PMID: 25701737
The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II. PMID: 21498573
hCAP-D3 is a new biomarker for subtype-1 prostate tumors that improves prognostication. PMID: 18223322
We show here that protein phosphatase 2A (PP2A), which interacts with condensin II but not condensin I, plays an essential role in targeting condensin II to chromosomes. PMID: 19915589
The CAP-D3 subunit of the condensin II complex implicated in chromosome assembly and segeregation PMID: 14532007

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Subcellular Location

Nucleus.

Database Links

HGNC: 28952

OMIM: 609276

KEGG: hsa:23310

STRING: 9606.ENSP00000433681

UniGene: Hs.438550

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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