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NCKIPSD Antibody

Datasheet
Code CSB-PA015534GA01HU
Size $600
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Product Details

Uniprot No.
Q9NZQ3
Target Names
NCKIPSD
Alternative Names
54 kDa VacA-interacting protein antibody; 54 kDa vimentin-interacting protein antibody; 90 kDa SH3 protein interacting with Nck antibody; AF3p21 antibody; dia interacting protein antibody; Dia-interacting protein 1 antibody; Diaphanous protein-interacting protein antibody; DIP antibody; DIP-1 antibody; DIP1 antibody; NCK interacting protein with SH3 domain antibody; NCK-interacting protein with SH3 domain antibody; Nckipsd antibody; ORF1 antibody; SH3 adapter protein SPIN90 antibody; SH3 protein interacting with Nck 90 kDa antibody; SPIN90 antibody; SPN90_HUMAN antibody; VIP54 antibody; WASLBP antibody; WASP-interacting SH3-domain protein antibody; WISH antibody; wiskott- Aldrich syndrome protein-interacting protein antibody; Wiskott-Aldrich syndrome protein-interacting protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human NCKIPSD
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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NCKIPSD Proteins

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Target Background

Function
Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.
Gene References into Functions
  1. Low SPIN90 expression is associated with Breast Cancer. PMID: 28652253
  2. findings suggest that SPIN90 contributes to the formation and movement of endosomal vesicles, and modulates the stability of EGFR protein, which affects cell cycle progression PMID: 24340049
  3. SPIN90 dephosphorylation is a prerequisite step for releasing cofilin so that cofilin can adequately sever actin filaments into monomeric form. PMID: 23765104
  4. Findings show that SPIN90 modulates synaptic activity in neurons as a result of its phosphorylation. PMID: 23342115
  5. Dia2 and DIP co-tether to nascent blebs and this linkage is required for bleb formation. PMID: 23024796
  6. the interaction of the betaPIX.WASP.SPIN90 complex with Nck is crucial for stable cell adhesion and can be dynamically modulated by SPIN90 phosphorylation that is dependent on cell adhesion and ERK activation PMID: 14559906
  7. SPIN90 participates in reorganization of the actin cytoskeleton and in actin-based cell motility PMID: 16253999
  8. These observations point to a pivotal role for DIP in the control of nonbranched and branched actin-filament assembly that is mediated by Diaphanous-related formins and activators of Arp2/3, respectively. PMID: 17398099
  9. DIP binds to and inhibits actin assembly by the FH2 domain of the formin mDia2 PMID: 17398099

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Involvement in disease
A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with KMT2A/MLL1.
Subcellular Location
Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
Tissue Specificity
Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen.
Database Links

HGNC: 15486

OMIM: 606671

KEGG: hsa:51517

STRING: 9606.ENSP00000294129

UniGene: Hs.655006

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