NCKIPSD Antibody

Datasheet

Code	CSB-PA015534GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q9NZQ3

Target Names

NCKIPSD

Alternative Names

54 kDa VacA-interacting protein antibody; 54 kDa vimentin-interacting protein antibody; 90 kDa SH3 protein interacting with Nck antibody; AF3p21 antibody; dia interacting protein antibody; Dia-interacting protein 1 antibody; Diaphanous protein-interacting protein antibody; DIP antibody; DIP-1 antibody; DIP1 antibody; NCK interacting protein with SH3 domain antibody; NCK-interacting protein with SH3 domain antibody; Nckipsd antibody; ORF1 antibody; SH3 adapter protein SPIN90 antibody; SH3 protein interacting with Nck 90 kDa antibody; SPIN90 antibody; SPN90_HUMAN antibody; VIP54 antibody; WASLBP antibody; WASP-interacting SH3-domain protein antibody; WISH antibody; wiskott- Aldrich syndrome protein-interacting protein antibody; Wiskott-Aldrich syndrome protein-interacting protein antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human NCKIPSD

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.

Gene References into Functions

Low SPIN90 expression is associated with Breast Cancer. PMID: 28652253
findings suggest that SPIN90 contributes to the formation and movement of endosomal vesicles, and modulates the stability of EGFR protein, which affects cell cycle progression PMID: 24340049
SPIN90 dephosphorylation is a prerequisite step for releasing cofilin so that cofilin can adequately sever actin filaments into monomeric form. PMID: 23765104
Findings show that SPIN90 modulates synaptic activity in neurons as a result of its phosphorylation. PMID: 23342115
Dia2 and DIP co-tether to nascent blebs and this linkage is required for bleb formation. PMID: 23024796
the interaction of the betaPIX.WASP.SPIN90 complex with Nck is crucial for stable cell adhesion and can be dynamically modulated by SPIN90 phosphorylation that is dependent on cell adhesion and ERK activation PMID: 14559906
SPIN90 participates in reorganization of the actin cytoskeleton and in actin-based cell motility PMID: 16253999
These observations point to a pivotal role for DIP in the control of nonbranched and branched actin-filament assembly that is mediated by Diaphanous-related formins and activators of Arp2/3, respectively. PMID: 17398099
DIP binds to and inhibits actin assembly by the FH2 domain of the formin mDia2 PMID: 17398099

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Involvement in disease

A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with KMT2A/MLL1.

Subcellular Location

Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.

Tissue Specificity

Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen.

Database Links

HGNC: 15486

OMIM: 606671

KEGG: hsa:51517

STRING: 9606.ENSP00000294129

UniGene: Hs.655006

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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