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NDUFS7 Antibody

Datasheet
Code CSB-PA015666ESR1HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NDUFS7 Polyclonal antibody
Uniprot No.
O75251
Target Names
NDUFS7
Alternative Names
CI 20 antibody; CI-20kD antibody; Complex I 20kDa subunit antibody; Complex I mitochondrial respiratory chain 20 KD subunit antibody; Complex I-20kD antibody; FLJ45860 antibody; FLJ46880 antibody; MGC120002 antibody; MY017 antibody; NADH coenzyme Q reductase antibody; NADH dehydrogenase (ubiquinone) Fe S protein 7 20kDa (NADH coenzyme Q reductase) antibody; NADH dehydrogenase (ubiquinone) FeS protein 7; 20kDa (NADHcoenzyme Q reductase) antibody; NADH dehydrogenase (ubiquinone) FeS protein7; 20kDa (NADHcoenzyme Q reductase) antibody; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7; mitochondrial antibody; NADH-ubiquinone oxidoreductase 20 kDa subunit antibody; NADH:ubiquinone oxidoreductase PSST subunit antibody; NADHcoenzyme Q reductase antibody; Ndufs7 antibody; NDUS7_HUMAN antibody; PSST antibody; PSST subunit antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial protein (39-213AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
Gene References into Functions
  1. However, similar to another family member, RdmB, it catalyzes the introduction of a hydroxyl group, in the case of NDUFAF5, into Arg-73 in the NDUFS7 subunit of human complex I PMID: 27226634
  2. no active role of NDUFS7 gene in schizophrenia, was found. PMID: 22935918
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
  4. A patient with Leigh syndrome (LS), born to consanguineous parents, with severe complex I defect and a novel mutation in the NDUFS7 gene subunit. PMID: 17275378
  5. Intronic NDUFS7 gene mutation is associated with activation of a cryptic exon and impaired assembly of mitochondrial complex I in a patient with Leigh syndrome PMID: 17604671
  6. Both the amount and intrinsic activity of complex I are decreased in inherited complex I deficiency, ehich can be increased by Trolox. PMID: 18435906
  7. Observational study of gene-disease association. (HuGE Navigator) PMID: 17601350
  8. Observational study of gene-disease association. (HuGE Navigator) PMID: 18977241

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Involvement in disease
Leigh syndrome (LS); Mitochondrial complex I deficiency (MT-C1D)
Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein Families
Complex I 20 kDa subunit family
Database Links

HGNC: 7714

OMIM: 252010

KEGG: hsa:374291

STRING: 9606.ENSP00000233627

UniGene: Hs.211914

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Related pathways
Oxidative Phosphorylation
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