NEK11 Antibody

Code CSB-PA844052LA01HU
Size US$166
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  • Western blot
    All lanes: NEK11 antibody at 7μg/ml + Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit at 1/10000 dilution
    Predicted band size: 75, 55, 56, 69 kDa
    Observed band size: 75 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA844052LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NEK11 Polyclonal antibody
Uniprot No.
Target Names
NEK11
Alternative Names
4932416N14Rik antibody; FLJ23495 antibody; NEK11 antibody; NEK11_HUMAN antibody; NEK11S/L antibody; Never in mitosis A-related kinase 11 antibody; NIMA (never in mitosis gene a) related kinase 11 antibody; NIMA (never in mitosis gene a)- related kinase 11 antibody; NIMA related kinase 11L antibody; NIMA related kinase 11S antibody; NIMA-related kinase 11 antibody; NimA-related protein kinase 11 antibody; Serine/threonine-protein kinase Nek11 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Serine/threonine-protein kinase Nek11 protein (245-482AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NEK11 Antibody (Product code: CSB-PA844052LA01HU) is Non-conjugated. For NEK11 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA844052LB01HU NEK11 Antibody, HRP conjugated ELISA
FITC CSB-PA844052LC01HU NEK11 Antibody, FITC conjugated
Biotin CSB-PA844052LD01HU NEK11 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
Gene References into Functions
  1. contributes to response of colorectal cancer cells to genotoxic agents and is essential for survival either with or without exposure to DNA damage PMID: 26501353
  2. Results show that downregulation of NEK11 in drug resistant cells might contribute to drug resistance in ovarian cancer. PMID: 24969318
  3. NEK11 controls degradation of CDC25A by directly phosphorylating CDC25A on residues whose phosphorylation is required for beta-TrCP mediated CDC25A polyubiquitylation and degradation. PMID: 20090422
  4. Nek11 has a role in the S-phase checkpoint downstream of the caffeine-sensitive pathway PMID: 12154088
  5. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells PMID: 15161910
  6. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. PMID: 19734889

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Subcellular Location
Nucleus. Nucleus, nucleolus.
Protein Families
Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
Tissue Specificity
Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
Database Links

HGNC: 18593

OMIM: 609779

KEGG: hsa:79858

STRING: 9606.ENSP00000372857

UniGene: Hs.657336

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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