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Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
Gene References into Functions
Overexpression of Neo1 significantly reduced the GC cell sensitivity to cisplatin and increased the cell viability, motility and adhesion ability, and while silencing of Neo1 showed contrary results. PMID: 30064133
Endogenous NTN4/NEO1 maintain neuroblastoma growth via both pro-survival and pro-migratory molecular signaling. PMID: 28038459
Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin. PMID: 27716118
these results suggested that GD3 recruits gamma-secretase to lipid/rafts, allowing efficient cleavage of neogenin. PMID: 27288875
The hemizygous 15q deletion unmasks the recessive functional polymorphism in NEO1 which plays a pivotal role in cortical interneuron development; study provides the first evidence linking NEO1 with autism spectrum disorders in humans PMID: 26518331
Neogenin influences both cadherin dynamics and junctional tension. PMID: 27029596
Ntn4 promotes the proliferation and motility of gastric cancer cells which is mediated by its receptor Neo and through further activation of multi-oncogenic pathways PMID: 25909166
The present study demonstrates that neogenin may be a tumor suppressor in breast cancer. Neogenin may serve as a potential diagnostic marker and therapeutic target for breast cancer. PMID: 25998984
These results show how repulsive guidance molecule acts as the central hub that links BMP2 and NEO1 and physically connects these fundamental signaling pathways. PMID: 25938661
Neogenin expression is inversely associated with breast cancer grade. PMID: 25416629
high-expression of neogenin-1 promotes gastric cancer proliferation and motility PMID: 24930499
miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin. PMID: 24657544
these results highlight Neogenin1 as a novel downstream effector of the Sonic Hedgehog pathway in medulloblastoma PMID: 23775842
two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner. PMID: 23744777
neogenin forms a ternary complex with both MT2 and HJV at the plasma membrane. The complex facilitates HJV cleavage by MT2, and release of the cleaved HJV from the cell occurs after a retrograde trafficking through the TGN/Golgi compartments. PMID: 22893705
pattern of distribution suggests that a functional netrin-4-neogenin pathway might be restricted to syncytiotrophoblasts, mesenchymal cells, and villous endothelial cells PMID: 22705235
the proposed role of neogenin as a tumor suppressor in gliomas PMID: 22666451
identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
Netrin-1 can promote the potential of proliferation and invasion of extravillous trophoblasts in vitro through its receptors neogenin and UNC5B. PMID: 19570425
Neogenin FN5, which does not bind hemojuvelin in isolation, exhibits a highly electropositive surface, which may be involved in interactions with negatively-charged polysaccharides or phospholipids in the membrane bilayer. PMID: 20971194
neogenin negatively regulates the functions of BMP and that this effect of neogenin is mediated by the activation of RhoA. PMID: 21149453
results show that different isoforms of hemojuvelin may play unique physiological roles through defined interactions with distinct signaling proteins such as BMP2 and neogenin, and demonstrate that some of these interactions are defective. PMID: 18287331
This study supports the hypothesis that, as in the embryo, neogenin regulates fundamental signalling pathways important for neurogenesis in the adult mouse and human forebrain. PMID: 20575069
neogenin and restin have roles in proproliferation/survival action on ovarian cancer cells PMID: 12833147
neogenin may play a role in mammary carcinogenesis as well as morphogenesis PMID: 16324219
HJV-induced BMP signaling and hepcidin expression are not altered by neogenin overexpression or by inhibition of endogenous neogenin expr PMID: 18326817
the neogenin intracellular domain regulates gene transcription via nuclear translocation PMID: 18391016
neogenin-mediated HJV release occurs after the HJV-neogenin complex is internalized from the cell surface PMID: 18445598
Results show that the serine/threonine kinase death-associated protein kinase (DAPK) is involved in the signal transduction of neogenin. PMID: 18583991
Results support that hepatic neogenin possesses two functions, mediation of cellular HJV release, and stimulation of HJV-enhanced hepcidin expression. PMID: 19564337
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Subcellular Location
Cell membrane; Single-pass type I membrane protein.