NFE2L3 Antibody, Biotin conjugated

Code CSB-PA896721LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NFE2L3 Polyclonal antibody
Uniprot No.
Target Names
NFE2L3
Alternative Names
NFE2L3 antibody; NRF3 antibody; Nuclear factor erythroid 2-related factor 3 antibody; NF-E2-related factor 3 antibody; NFE2-related factor 3 antibody; Nuclear factor antibody; erythroid derived 2 antibody; like 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Nuclear factor erythroid 2-related factor 3 protein (132-260AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Activates erythroid-specific, globin gene expression.
Gene References into Functions
  1. SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM. PMID: 28554271
  2. findings reveal FBW7 and GSK3 as novel regulators of the NFE2L3 transcription factor and a potential mechanism by which FBW7 might regulate detoxification and the cellular response to stress PMID: 26306035
  3. 17beta-Estradiol treatment significantly increased but VC or Res decreased Nrf3 mRNA and protein expression levels. PMID: 25130429
  4. Nrf3 is a negative regulator of ARE-mediated gene expression of NQO1 PMID: 15385560
  5. NRF3 is highly expressed in primary placental cytotrophoblasts PMID: 15388789
  6. Nrf3 is an N-glycosylated protein associated with the endoplasmic reticulum PMID: 17976382

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Subcellular Location
Nucleus.
Protein Families
BZIP family, CNC subfamily
Tissue Specificity
Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.
Database Links

HGNC: 7783

OMIM: 604135

KEGG: hsa:9603

STRING: 9606.ENSP00000056233

UniGene: Hs.404741

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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