NFKBIA Antibody

1. this study shows changes of NF-kB expression levels induced by cell-free DNA in different cell types PMID: 29743966
2. the results of real-time PCR and western blotting revealed that Huaier extract decreased p65 and c-Met expression and increased IkappaBalpha expression, while paclitaxel increased p65 expression and reduced IkappaBalpha and c-Met expression.The molecular mechanisms may be involved in the inhibition of the NF-kappaB pathway and c-Met expression PMID: 29039556
3. Colorectal cancer cases showed an increase in the frequency of NFkappaBIA-881G allele in Egyptian subjects. PMID: 28389768
4. association between polymorphisms and progression of chronic hepatitis B Virus infection among Chinese Han Population PMID: 29093318
5. miR-668 was upregulated in radioresistant human breast cancer cell lines MCF-7R and T-47DR, which targeted IkappaBalpha, activated the NF-kappaB pathway and thus increased the radioresistance of breast cancer cells. PMID: 28138801
6. We showed that pristimerin suppressed tumor necrosis factor a (TNFalpha)-induced IkappaBa phosphorylation, translocation of p65, and expression of NFkappaB-dependent genes. Moreover, pristimerin decreased cell viability and clonogenic ability of Uveal melanoma (UM)cells. A synergistic effect was observed in the treatment of pristimerin combined with vinblastine, a frontline therapeutic agent, in UM. PMID: 28766683
7. Data collectively demonstrate the functional importance of IkappaBalpha-mediated stripping of NFkappaB from DNA in the kinetic control of NFkappaB signaling. PMID: 28167786
8. These findings indicate that genetic polymorphisms of NFKB1A rs696, pre-miR-146a rs2910164 and pre-miR-499 rs3746444 may represent novel markers of AT susceptibility. PMID: 28674224
9. XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IkappaBalpha and overcomes acquired proteasome inhibitor resistance in human multiple myeloma. PMID: 27806331
10. Molecular docking analysis indicated that transcription factor NF-kappaB was one of the potential molecular targets modulated by DTTF. Specifically, the drug blocked the TNFalpha-induced phosphorylation of upstream IkappaBalpha kinase in a time-dependent manner leading to the suppression of NF-kappaB activation and nuclear translocation PMID: 27882436
11. We show that HOTAIR regulates activation of NF-kB by decreasing Ik-Ba (NF-kB inhibitor) and establish that by inducing prolonged NF-kB activation and expression of NF-kB target genes during DNA damage, HOTAIR has a critical role in cellular senescence and platinum sensitivity PMID: 27041570
12. Here, the authors report amide hydrogen/deuterium exchange data that reveal long-range allosteric changes in the NFkappaB (RelA-p50) heterodimer induced by DNA or IkappaBalpha binding. PMID: 28249778
13. Sam68 is essential for DNA damage-induced NF-kappaB activation and colon tumorigenesis. PMID: 27458801
14. Specifically, BCA2 serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the sequestration of NF-kappaB components in the cytoplasm. Since HIV-1 utilizes NF-kappaB to promote proviral transcription, the BCA2-mediated inhibition of NF-kappaB significantly decreases the transcriptional activity of HIV-1. PMID: 28122985
15. This study found that NFKBIA mRNAs was significantly expressed in normal tissues compared with glioma specimens. PMID: 27538656
16. Findings indicate the prognostic value of NFKB inhibitor alpha (NFKBIA) in lower-grade gliomas (LGGs). PMID: 27052952
17. W346 effectively inhibited tumor necrosis factor (TNF-a)-induced NF-kappaB activation by suppressing IKK phosphorylation, inhibiting IkB-a degradation, and restraining the accumulation of NF-kappaB subunit p65 nuclear translocation. W346 also affected NF-kappaB-regulated downstream products involved in cycle arrest and apoptosis. PMID: 26520440
18. treating cells with SZC014 resulted in a decrease in phosphorylation of IkBa and NF-kappaB/p65 and NF-kappaB/p65 nuclear translocation. The cytotoxic activities of seven OA derivatives were generally stronger than that of OA, among which, SZC014 possessed the most potent anticancer activity in SGC7901 cells and would be a promising chemotherapic agent for the treatment of gastric cancer PMID: 26547583
19. Network analysis identified NFKBIA as pathogenic gene in childhood asthma. PMID: 27420950
20. HMBA was able to increase prostratin-induced phosphorylation and degradation of NF-kappaB inhibitor IkappaBalpha, thereby enhancing and prolonging prostratin-induced nuclear translocation of NF-kappaB, a prerequisite for stimulation of transcription initiation PMID: 27529070
21. enhanced miR-381a-3p expression contributed to the injury of osteoarthritis mainly by inhibiting the expression of IkappaBalpha. PMID: 27312547
22. Timely and efficient degradation of ubiquitinated IkappaB[alpha], concomitant with timely and efficient liberation of RelA from ubiquitinated IkappaB[alpha] and RelA nuclear translocation, essentially depends on the presence of functional p97/VCP. PMID: 26463447
23. Activated Rac1 regulates the degradation of IkappaBalpha and the nuclear translocation of STAT3-NFkappaB complexes in starved cancer cells PMID: 27151455
24. mutation in Chinese patient results in mycobacterial infections without ectodermal dysplasia PMID: 26691317
25. DAT stabilized IkBa by inhibiting the phosphorylation of Ika by the IkB kinase (IKK) complex. DAT induced proteasomal degradation of TRAF6, and DAT suppressed IKKb-phosphorylation through downregulation of TRAF6 PMID: 26647777
26. the rs3138053 polymorphism of NFKBIA gene is a candidate for susceptibility to overall cancers, while rs696 plays a protective role [meta-analysis] PMID: 26488500
27. Identify a novel BCR-ABL/IkappaBalpha/p53 network, whereby BCR-ABL functionally inactivates a key tumor suppressor in chronic myeloid leukemia. PMID: 26295305
28. Study demonstrates an association between functional polymorphisms of IkappaBalpha rs696 and smoking with the risk of defective spermatogenesis, suggesting some interaction between the NF-kappaB signalling pathway and smoking-related ROS in human spermatogenesis. PMID: 25352423
29. genetic variation associated with susceptibility to acute kidney injury PMID: 26477820
30. MicroRNA-19a mediates gastric carcinoma cell proliferation through the activation of IkappaBalpha. PMID: 26239140
31. No association was observed between NFKBIA variants and risk of liver cancer. PMID: 24578542
32. SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades. PMID: 25937534
33. Data suggest that activity of IKBalpha can be regulated by dietary factors; dietary supplementation with luteolin inhibits vascular endothelial inflammation by suppressing IKBalpha/NFkappaB signaling. PMID: 25577468
34. This review and meta-analysis of the association of NFKBIA -881 A>G polymorphism with cancer susceptibility reveals that -881 A>G polymorphism may increase risk of cancer development in Asian populations. PMID: 26252270
35. miR-126 may play an important role in hepatic fibrosis by downregulating the expression of IkappaBalpha partly through the NF-kappaB signaling pathway. PMID: 25974152
36. IkappaBetaalpha inhibits apoptosis at the outer mitochondrial membrane independently of NF-kappaB retention. PMID: 25361605
37. The single nucleotide polymorphism rs1957106 CT and TT genotypes were found to be associated with lower NFKBIA protein levels and a poor prognosis of pateints with glioblastoma. PMID: 25215581
38. data suggest that the NFKBIA 126 G/A polymorphism might be potentially helpful to identify liver transplant recipients with an increased susceptibility to develop recurrent acute rejections PMID: 25112903
39. Expression of IkappaBalpha in human bladder cancer cells is negatively correlated with epithelial-mesenchymal transition and tumor invasion in vitro. PMID: 25374080
40. NFKBIA-rs2233419AG was associated with a significantly increased risk of developing recurrent wheezing. PMID: 25326706
41. miR-196a can directly interact with IkappaBalpha 3'-UTR to suppress IkappaBalpha expression and subsequently promote activation of NF-kappaB PMID: 24463357
42. MiR-196a promotes pancreatic cancer progression by targeting nuclear factor kappa-B-inhibitor alpha. PMID: 24504166
43. Data indicate that following bortezomib treatment there was accumulation of IkappaB-alpha (IkappaBalpha) without affecting its phosphorylation status at an early time point. PMID: 23697845
44. This study reveals that polymorphisms in the IkB-alpha promoter (-881 A/G, -826 C/T) are strongly associated with the susceptibility of Iranian Multiple Sclerosis patients PMID: 24368589
45. The results of this study suggested that oligodendroglial IkappaBalpha expression and NF-kappaB are activated early in the course of MSA and their balance contributes to the decision of cellular demise. PMID: 24361600
46. No statistically significant CRC risk association was found for the NFKBIA polymorphisms. PMID: 23996241
47. data indicate that NFKBIA deletions are present but not frequent in Glioblastoma multiforme (GBM); the deletions become frequent in GBM neurospheres (NS), an event that seems to be affected by the presence of EGF in the culture medium PMID: 24330732
48. the analysis of IkappaBalpha expression at salivary gland epithelial cell level could be a potential new hallmark of Sjogren's syndrome progression. PMID: 23377923
49. IkappaBalpha sequesters not only p65 but also RPS3 in the cytoplasm. PMID: 24457201
50. NF-kB expression was downregulated and its cytoplasmatic inhibitor IKBalpha was increased in CTLA4-Ig treated macrophages. PMID: 24295474
51. Data indicate that the p97-UFD1L-NPL4 protein complex specifically associates with ubiquitinated IkappaBalpha via the interactions between p97 and the SCF(beta-TRCP) ubiquitin ligase. PMID: 24248593
52. long-term incubation with PIs activates NF-kappaB, which is mediated by IkappaBalpha degradation via the lysosome in an IKK-dependent and IKK-independent manner. PMID: 24085292
53. Epithelial-mesenchymal transformation, along with acquisition of a tumor stem cell-like phenotype mediated by IKKbeta/IkappaBalpha/RelA signal pathway via Snail, contributes to a low concentration of arsenite-induced tumorigenesis. PMID: 23069812
54. These data show that I-kappa-B-alpha can be used as a prognostic marker and target for therapy in Activated B-cell lymphoma, one of the three subtypes of Diffuse Large B-cell Lymphoma. PMID: 23555990
55. The findings from this human cell study in vitro indicate that both relatively high single-dose and chronic opioid exposure may induce the structural changes in the developing human brain and the adult brain by altering the expression of neuronal differentiation- and neurite outgrowth-related genes IkappaBa and TrkB in vivo. PMID: 23422506
56. the silencing of NFKBIA may play an important role in the carcinogenesis of adenocarcinomas independent of EGFR/K-ras mutations or EML4-ALK fusion. PMID: 23439505
57. NFKB1 -94 Ins promoter polymorphism increased the risk of hepatocellular carcinoma (HCC), and may be applied as a predictive factor for the clinical stage and tumor size in female HCC patients. PMID: 23457512
58. miR-126 may play roles in UC inflammatory activity by down-regulating the expression of IKBA, an important inhibitor of NF-kappaB signaling pathway. PMID: 23285182
59. Immunologically relevant genetic variation in the promoter of NFKBIA is differentially susceptibile to severe bronchiolitis following infection with respiratory syncytial virus, airway hyperresponsiveness, and severe bronchopulmonary dysplasia. PMID: 23487427
60. Pokemon activates the expression of both p65 and IkappaBalpha by sequence-specific binding to their promoters and plays a dual role in regulating NF-kappaB signaling. PMID: 23054188
61. Authors discover that HIV-1 infection elevates the phosphorylation of IkappaBalpha and p100, and that this increase is greatly reduced when a Vpr-negative HIV-1 is used for infection. PMID: 23453579
62. Our findings clearly demonstrate changes in the levels of IkappaBalpha in Sjogren's syndrome monocytes, suggesting that the attenuated expression of IkappaBalpha could contribute to the deregulation of NF-kappaB pathways in Sjogren's syndrome pathogenesis. PMID: 22935973
63. YLTA mutations stabilize the I-kappa-B-alpha to proteasomal degradation. PMID: 23274114
64. TOPK directly interacted with and phosphorylated IkappaBalpha at Ser-32, leading to p65 nuclear translocation and NF-kappaB activation. PMID: 23250755
65. The expressions of NF-kappaBp65 and IkappaBalpha are negatively correlated in gestational trophoblastic tumor tissues. PMID: 23046941
66. bortezomib-induced autophagy confers relative DLBCL cell drug resistance by eliminating I-kappaBalpha. PMID: 22393418
67. MIB1 negatively regulates TNFalpha- and IL1beta- induced NF-kappaB target gene activation PMID: 22184009
68. The endothelium plays important roles in obesity- and age-related disorders through intracellular NF-kappaB signaling, thereby ultimately affecting life span. PMID: 22302838
69. A novel mutation in the IKBA gene was discovered in an infant with autosomal-dominant anhidroticectodermal dysplasia with immune deficiency syndrome PMID: 22078572
70. in glioma cell lines that microRNA-30e* (miR-30e*) directly targets the IkappaBalpha 3'-UTR and suppresses IkappaBalpha expression PMID: 22156201
71. These results suggest the existence of a reservoir of monoubiquitylated IkappaBalpha resistant to TNFalpha-induced proteolysis. PMID: 22022389
72. The allele frequency and genotype distribution of NFKBIA gene polymorphism did not differ between myocardial infarction and control group. PMID: 20304615
73. deletion of NFKBIA and amplification of EGFR show a pattern of mutual exclusivity in glioblastoma multiforme[review] PMID: 21778941
74. Data show that IkappaB kinase beta (IKKbeta) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha. PMID: 21606193
75. CCL5 signaling induces GLI2 through a PI3K-AKT-IkappaBalpha-p65 pathway and requires GLI2 transcriptional activity to modulate IL-6 expression and Ig secretion in vitro and in vivo PMID: 21454528
76. NFKBIA low mutation frequency plays a minor role in the NF-kappaB activity of nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL), suggesting different mechanisms of NF-kappaB activation in NLPHL compared to classical Hodgkin's lymphoma (cHL). PMID: 19648161
77. IkBalpha promoter polymorphisms are related to susceptibility to ankylosing spondylitis in Taiwan. PMID: 19363678
78. rs17103265 deletion homozygote is a genetic risk factor for gastric cancer, especially for certain subtypes in a southern Chinese population PMID: 21376060
79. alpha-1-antitrypsin blocks nuclear translocation of NF-kappaB p50/p65 despite an unexpected elevation in associated phosphorylated and ubiquitinated IkappaBalpha. PMID: 21263074
80. gene polymorphisms is associated with the development of asthma in Korea PMID: 20674643
81. This meta-analysis demonstrates that autoimmune and inflammatory diseases are associated with NFKBIA gene -826C/T polymorphism, but not with 2758A/G, -881A/G, and -279C/T. PMID: 20495844
82. promoter polymorphism is associated with susceptibility to rheumatoid arthritis in Taiwain PMID: 20563630
83. Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival. PMID: 21175304
84. Polymorphism in NFkB was associated with colorectal cancer. PMID: 20836841
85. alpha-mangostin also strongly inhibited PMA-induced degradation of inhibitor of kappaBalpha (IkappaBalpha) PMID: 20652762
86. Although p65 recruitment to TNF-alpha, IL-1ss, and IL-6 promoters is inhibited by nuclear IkappaBkappaalpha, recruitment to interleukin (IL)-8 promoter is not repressed. PMID: 20696864
87. Total and phosphorylated IkappaBalpha protein expression might serve as markers for NF-kappaB activation in human ovarian carcinoma. PMID: 20546338
88. Nuclear IKKbeta acts as an adaptor protein for IkappaBalpha degradation in UV-induced NF-kappaB activation. NF-kappaB activated by the nuclear IKKbeta adaptor protein suppresses anti-apoptotic gene expression and promotes UV-induced cell death. PMID: 20797629
89. Data show that RSK2 is activated by treatment with tumor necrosis factor-alpha (TNF-alpha) and directly phosphorylates IkappaBalpha at Ser-32, leading to IkappaBalpha degradation. PMID: 20385620
90. TGase 2-mu-calpain system is significant in the NF-kappaB pathway via I-kappaBalpha polymerization and subsequent degradation. PMID: 20659425
91. Subjects with at least one A allele for NFKBIA rs1951276 had approximately 29% lower insulin sensitivity compared to individuals homozygous for the G allele... PMID: 19798070
92. Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation. PMID: 20335171
93. I kappaB alpha rs2233408 T heterozygotes were associated with reduced risk of gastric cancer, especially for the development of certain subtypes of gastric cancer in Chinese population. PMID: 20132559
94. IKBA -826T allele, IKBA -881A -826T -550A -519C -297C haplotype, and IKBA -881A -826T -550A -519T -297C haplotype may be related to susceptibility to Behcet's disease. IKBA -826T/T is associated with skin lesions in patients with Behcet's disease. PMID: 20164548
95. NFKBIA mRNA was strongly expressed in H-RS cells from Hodgkin lymphoma sections, and little was detected in the reactive surrounding lymphocytes. PMID: 20193848
96. Case report. this patient's IkappaBalpha mutation caused GH and IGF-l resistance which, in turn, contributed to his growth failure. PMID: 20080849
97. Aurora-A, via activating Akt, stimulated nuclear factor-kappaB signaling pathway to promote cancer cell survival. PMID: 19891769
98. IkappaBalpha x p53 complex plays an important role in responses involving growth regulation, apoptosis, and hypoxic stress PMID: 11799106
99. A novel in vitro assay for deubiquitination of I kappa B alpha PMID: 11913973
100. NF-kappa Beta activation in BAL cells may play in important role in initiation and progression of silica-induced pulmonary inflammation, cellular damage, and fibrosis PMID: 12028809

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HGNC: 7797

OMIM: 164008

KEGG: hsa:4792

STRING: 9606.ENSP00000216797

UniGene: Hs.81328