Product Details

Uniprot No.

Target Names

NFKBIA

Alternative Names

NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from Human IκB-α around the non-phosphorylation site of S32/S36.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, IF, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Still Have Questions?

Leave a Message or Start an on-line Chat

Citations

The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia. Dongdong Zhang, et al,Free Radical Biology and Medicine,2019

Sample type: AML cell lines
Sample species: Mouse
Application: WB
Review: AML cells were treated with 1 µM A-Z2 for 24 h, cell supernatants were harvested, cytochrome c level was measured by ELISA. Apoptosis (F) and cell cycle were analyzed after Molm-13 were treated with 1 µM A-Z2 for 24 h. AML-PC: AML patient primary cell.
PMID: 31730934

Genistein improves schistosomiasis liver granuloma and fibrosis via dampening NF-kB signaling in mice. Chunpeng Wan.et al,Parasitology Research,2017

Application: Mouse liver tissues
Sample type: Peripheral blood neutrophils
Review: Representative western blots for IκB, phosphor-IκB, p65, and phospho-p65 expressions in mouse liver tissues.
PMID: 28160073

Target Data

Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Involvement in disease	Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency autosomal dominant (ADEDAID)
Subcellular Location	Cytoplasm, Nucleus
Protein Families	NF-kappa-B inhibitor family
Database Links	HGNC: 7797 OMIM: 164008 KEGG: hsa:4792 STRING: 9606.ENSP00000216797 UniGene: Hs.81328

CloseMessage

Product >> Product Name：
Product >> Code：
Product >> Size：
Name： *
Email： *
Phone：
We recommend you to leave your phone number because occasionally our emails get flagged by spam filters. We would not disclose any of your private information to any third party.
Question/Comment： *
Your Region： *
Country State：
I'd like to receive email newsletters from Cusabio

Yes

No
How did you know this promotion?

Email

Distributor

Search engine

Advertisement

Others
Check Code：

Code	CSB-PA010535
Size	US$167
Image	Western Blot analysis of HuvEc cells using IκB-α Polyclonal Antibody

NFKBIA Antibody

Product Details

Citations

Related Products

Target Data

Most popular with customers

CloseMessage