Code | CSB-PA010535 |
Size | US$167 |
Image |
Uniprot No. | P25963 | ||||||||||
Target Names | NFKBIA | ||||||||||
Alternative Names | NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3 | ||||||||||
Raised in | Rabbit | ||||||||||
Species Reactivity | Human,Mouse,Rat | ||||||||||
Immunogen | Synthesized peptide derived from Human IκB-α around the non-phosphorylation site of S32/S36. | ||||||||||
Immunogen Species | Homo sapiens (Human) | ||||||||||
Conjugate | Non-conjugated | ||||||||||
Isotype | IgG | ||||||||||
Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | ||||||||||
Concentration | It differs from different batches. Please contact us to confirm it. | ||||||||||
Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. | ||||||||||
Form | Liquid | ||||||||||
Tested Applications | WB, IHC, IF, ELISA | ||||||||||
Recommended Dilution |
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Protocols | Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol ELISA Protocol |
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Troubleshooting and FAQs | Antibody FAQs | ||||||||||
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||||||
Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. | ||||||||||
Still Have Questions? | Leave a Message or Start an on-line Chat |
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The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia. Dongdong Zhang, et al,Free Radical Biology and Medicine,2019 Sample type: AML cell lines |
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Genistein improves schistosomiasis liver granuloma and fibrosis via dampening NF-kB signaling in mice. Chunpeng Wan.et al,Parasitology Research,2017 Application: Mouse liver tissues |
Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
Involvement in disease | Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency autosomal dominant (ADEDAID) |
Subcellular Location | Cytoplasm, Nucleus |
Protein Families | NF-kappa-B inhibitor family |
Database Links |
HGNC: 7797 OMIM: 164008 KEGG: hsa:4792 STRING: 9606.ENSP00000216797 UniGene: Hs.81328 |
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