NME8 Antibody

Datasheet

Code	CSB-PA889073
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA889073(NME8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8N427

Target Names

NME8

Alternative Names

NME8 antibody; SPTRX2 antibody; TXNDC3 antibody; Thioredoxin domain-containing protein 3 antibody; NM23-H8 antibody; NME/NM23 family member 8 antibody; Spermatid-specific thioredoxin-2 antibody; Sptrx-2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human NME8

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.

Gene References into Functions

Studies suggest that the rs2718058 near gene NME8 on chromosome 7p14.1 might not play a major role in the genetic predisposition to late-onset Alzheimer's disease (LOAD) in the North Han Chinese. PMID: 27144521
Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8) was nominally associated with change on the DWRT, DSST, and WFT, respectively, in whites. PMID: 27781389
NME8 locus polymorphism is associated with cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease. PMID: 25486118
GPR141-NME8 locus had strong genetic effect on the susceptibility to generalized periodontitis in Japanese individuals with history of smoking. identified 2 suggestive loci for periodontitis in a Japanese population. PMID: 25672891
Our approach yielded 26 candidate genes differentially expressed between patients (Osteoarthritis) and controls. The presence of allelic imbalances confirms cis-regulatory mechanisms for RHOB and TXNDC3. PMID: 16642435
genetic association of RHOB and TXNDC3 with osteoarthritis was detected PMID: 17304710
Primary ciliary dyskinesia is caused by an SNP-induced modification of the ratio of two physiological isoforms of TXNDC3 generated by alternative splicing. PMID: 17360648
The minor allele frequencies of TXNDC3 in East Asian individuals are significantly different from those in United Kingdom control individuals. PMID: 18471322

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Involvement in disease

Ciliary dyskinesia, primary, 6 (CILD6)

Subcellular Location

Cytoplasm.

Protein Families

NDK family

Tissue Specificity

Testis-specific. Expressed only in primary spermatocytes and round spermatids.

Database Links

HGNC: 16473

OMIM: 607421

KEGG: hsa:51314

STRING: 9606.ENSP00000199447

UniGene: Hs.723454

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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