NME8

The protein encoded by NME8, also known as NDP kinase 8 or nm23-H8, is a member of the nucleoside diphosphate kinase (NDPK) family. It exhibits nucleotide phosphotransferase activity, regulating intracellular nucleotide pools and participating in energy metabolism. NME8 is primarily associated with mitochondrial function, contributing to ATP production and maintaining mitochondrial membrane potential.
Dysregulation of NME8 has been linked to mitochondrial disorders and oxidative phosphorylation defects, potentially contributing to neurodegenerative diseases and metabolic syndromes. Current research focuses on its role in mitochondrial dynamics, though specific therapeutic agents targeting NME8 are still in preclinical stages, with studies exploring its utility as a diagnostic biomarker for mitochondrial dysfunction.