NPAS1 Antibody

Code CSB-PA015966GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
NPAS1
Alternative Names
NPAS1 antibody; BHLHE11 antibody; MOP5 antibody; PASD5 antibody; Neuronal PAS domain-containing protein 1 antibody; Neuronal PAS1 antibody; Basic-helix-loop-helix-PAS protein MOP5 antibody; Class E basic helix-loop-helix protein 11 antibody; bHLHe11 antibody; Member of PAS protein 5 antibody; PAS domain-containing protein 5 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human NPAS1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH.
Gene References into Functions
  1. Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions. PMID: 28499489
  2. Here the authors examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. PMID: 27782878
Subcellular Location
Nucleus.
Database Links

HGNC: 7894

OMIM: 603346

KEGG: hsa:4861

STRING: 9606.ENSP00000405290

UniGene: Hs.79564

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