NR2C1 Antibody

Code CSB-PA016051ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA016051ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA016051ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) NR2C1 Polyclonal antibody
Uniprot No. P13056
Target Names NR2C1
Alternative Names NR2C1 antibody; TR2 antibody; Nuclear receptor subfamily 2 group C member 1 antibody; Orphan nuclear receptor TR2 antibody; Testicular receptor 2 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Nuclear receptor subfamily 2 group C member 1 protein (1-240AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Gene References into Functions
  1. DRED is a 540 kDa complex containing the nuclear orphan receptors TR2 and TR4, which form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites. TR2 & 4 mRNAs are expressed at all stages of murine and human erythropoiesis. PMID: 12093744
  2. TR2 that may exert an important repressor in regulating ER activity in mammary glands. PMID: 12093804
  3. TR2 and TR4 can have distinct functions. Existence of differential and bi-directional regulation between PPAR alpha and TR2/TR4. Possible roles in PPAR alpha signaling pathway in human keratinocytes. PMID: 12615366
  4. TR2 may function as a negative modulator to suppress androgen receptor function in prostate cancer. Further studies on how to control TR2 function may result in the ability to modulate AR function in prostate cancer. PMID: 12949936
  5. The NF1-A transcription factor plays an important role in the transcriptional activation of the TR2 gene expression via a promoter activating cis-element. PMID: 17010934

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Subcellular Location Nucleus, Nucleus, PML body
Protein Families Nuclear hormone receptor family, NR2 subfamily
Database Links

HGNC: 7971

OMIM: 601529

KEGG: hsa:7181

STRING: 9606.ENSP00000333275

UniGene: Hs.108301

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