NRDC Antibody

1. NRDC expression was reduced in infarcted regions in autopsy samples from acute myocardial ischemia patients. PMID: 28747015
2. Gene expression level of NRD1 is significantly higher in AD patients when compared to normal controls. PMID: 26943237
3. MRNA expression of NRD1 was upregulated in 56% of ESCC tissue samples. PMID: 24168165
4. This study demonistrated that alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism. PMID: 23219461
5. possible roles of nardilysin in Alzheimer disease, Down syndrome, schizophrenia, mood disorders, alcohol abuse, heroin addiction and cancer; show that nardilysin is a Janus-faced enzyme with regard to brain pathology-- probably neuropathogenic in some diseases, but neuroprotective in others [review] PMID: 23604405
6. SH-SY5Y cells, stably transfected with green fluorescent protein-tagged-p42(IP4) show enhanced NRD protein expression already at an earlier time point after retinoic acid stimulation. PMID: 21801775
7. NRD1 interacts with p53 mutant R273H PMID: 22653443
8. These results demonstrate that gastric cancer cell growth is maintained by autonomous TNF-alpha-NF-kappaB and IL-6-STAT3 signalling, and that NRDc and ADAM proteases turn on these signalling cascades by stimulating ectodomain shedding of TNF-alpha. PMID: 22351606
9. Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. PMID: 22294699
10. Several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample for KIAA0040, NRD1 and THSD7B, respectively. PMID: 21703634
11. Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-alpha1 (ADAP1). PMID: 21972134
12. mediates antigen processing that generates cytotoxic T cell epitopes PMID: 21151101
13. nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF) PMID: 12095415
14. Nardilysin has an essential role in HB-EGF ectodomain shedding, which is regulated by the modulation of sheddase activity PMID: 16923819
15. We found high staining intensity in the hypothalamus, neocortex and brain stem nuclei. The cellular localization is almost exclusively confined to neurons. In pre- and perinatal human brain cortex, most neurons express the enzyme. PMID: 17442499
16. These results indicate the involvement of NRDc in ectodomain shedding of TNF-alpha. PMID: 18355445
17. Nardilysin convertase regulates the function of the maxi-K channel isoform mK44 in human myometrium. PMID: 19118164
18. N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor (HB-EGF) that modulates HB-EGF-induced cell migration. PMID: 11432822
19. The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain. PMID: 11478915

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HGNC: 7995

OMIM: 602651

KEGG: hsa:4898

STRING: 9606.ENSP00000346890

UniGene: Hs.584782