NRG4 Antibody, HRP conjugated

Code CSB-PA848829LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NRG4 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
DKFZp779N0541 antibody; DKFZp779N1944 antibody; Heregulin 4 antibody; HRG4 antibody; Neuregulin 4 antibody; Neuregulin-4 antibody; NRG-4 antibody; NRG4 antibody; NRG4_HUMAN antibody; pro-neuregulin-4; membrane-bound isoform antibody; Pro-NRG4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pro-neuregulin-4, membrane-bound isoform protein (1-115AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Gene References into Functions
  1. Nrg4 is highly and preferentially expressed in healthy adipocytes, while its expression was substantially reduced in obesity. Nrg4 activated endothelial angiogenic functions and angiogenesis both in vitro and in vivo. PMID: 29902456
  2. Serum NRG4 values were significantly elevated in the Gestational Diabetes Mellitus (GDM) group compared to the control group and is associated with metabolic parameters of GDM. PMID: 29282998
  3. circulating Nrg4 concentrations are inversely associated with subclinical atherosclerosis in obese adults; circulating Nrg4 might play a role in identifying patients at high risk for cardiovascular disease PMID: 27819316
  4. The circulating Nrg4 level is elevated in the prediabetic and diabetic patients compared to control and is an independent risk factor associated with diabetes. PMID: 27862843
  5. High serum Nrg4 levels are associated with type 2 diabetes mellitus. PMID: 27329015
  6. NRG4 and its receptor ErbB4 are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 signaling may be a novel pathway for therapeutic intervention or prevention in NEC. PMID: 25216938
  7. Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD). PMID: 26476959
  8. results establish Nrg4 as a brown fat-enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). PMID: 25401691
  9. Pharmacological inhibition of PI3K/Akt signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival PMID: 23033483
  10. The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4. PMID: 21805036
  11. NRG4 overexpression is associated with advanced-stage prostate cancer PMID: 17545517
  12. describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide PMID: 17684490
  13. NRG4 was positive in almost all breast cancers studied. PMID: 17962208
  14. Neuregulin-4 expression is downregulated during urinary bladder cancer progression PMID: 15583696

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Subcellular Location
[Pro-neuregulin-4, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-4]: Secreted.
Protein Families
Neuregulin family
Database Links

HGNC: 29862

OMIM: 610894

KEGG: hsa:145957

STRING: 9606.ENSP00000378367

UniGene: Hs.732438

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