NSMAF Antibody, HRP conjugated

Code CSB-PA856416LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NSMAF Polyclonal antibody
Uniprot No.
Target Names
NSMAF
Alternative Names
NSMAF antibody; FANProtein FAN antibody; Factor associated with neutral sphingomyelinase activation antibody; Factor associated with N-SMase activation antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein FAN protein (1-233AA )
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
Gene References into Functions
  1. these data identify a novel caspase-2-interacting factor, FAN, and expand the role for the enzyme in seemingly non-apoptotic cellular mechanisms. PMID: 29621545
  2. The rs1050504 C > T genotype was observed to be significantly associated with an increased risk for developing pulmonary tuberculosis. PMID: 29115933
  3. The interaction of FAN with receptor for activated C-kinase 1 (RACK1) appears to be dependent on the folding of the WD repeats into a secondary structure, because no linear binding motifs are identified in the WD-repeat region of FAN. PMID: 12391233
  4. sphingolipid activator proteins like domain may stabilize the fold of acid sphingomyelinase PMID: 15653433
  5. Regulation of NSMAF by TNF-alpha involves PRKCD in lung epithelial cells. PMID: 18653803

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Tissue Specificity
Ubiquitous.
Database Links

HGNC: 8017

OMIM: 603043

KEGG: hsa:8439

STRING: 9606.ENSP00000411012

UniGene: Hs.372000

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