NTNG1 Antibody

Code CSB-PA016131GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
NTNG1
Alternative Names
Axon guidance molecule antibody; KIAA0976 antibody; Laminet 1 antibody; LMNT1 antibody; Netrin G1f antibody; Netrin-G1 antibody; Ntng1 antibody; NTNG1_HUMAN antibody; YLSR571 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human NTNG1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
Gene References into Functions
  1. examined the hypothesis that NTNG1 allelic variation contributes to the risk for schizophrenia PMID: 25325217
  2. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. PMID: 23986473
  3. Our finding nominates the minor G allele of the NTNG1 rs628117 single nucleotide polymorphism as a risk factor for ischemic stroke at least in Armenian population. PMID: 23769687
  4. Genotype and allele frequencies of single nucleotide polymorphisms on NTNG1 are significantly associated with schizophrenia. PMID: 22227940
  5. Netrin-G1 is an important part of the NGL-1 receptor and functions to promote the outgrowth of dorsal thalamic axons. PMID: 14595443
  6. findings suggest that netrin G1 or a nearby gene may contribute to overall genetic risk for schizophrenia PMID: 15508520
  7. Specific haplotypes encompassing alternatively spliced exons of NTNG1 were associated with schizophrenia, and concordantly, messenger ribonucleic acid isoform expression was significantly different between schizophrenic and control brains. PMID: 15705354
  8. Sequence analysis of the cloned junction fragment indicated that on chromosome 1 the predominantly brain-expressed Netrin G1 (NTNG1) gene is disrupted, whereas on chromosome 7 there was no indication for a truncated gene PMID: 15870826
  9. NTNG1 may use alternative splicing to diversify its function in a developmentally and tissue-specific manner. PMID: 15901489
  10. Mutations in the NTNG1 gene appear to be a rare cause of Rett syndrome but NTNG1 function demands further investigation in relation to the central nervous system pathophysiology of the disorder. PMID: 16502428
  11. The data of this stusty implicate NTNG1 in the pathophysiology of schizophrenia and bipolar disorder, but do not support the hypothesis that altered mRNA expression is the mechanism by which genetic variation of NTNG1 may confer disease susceptibility. PMID: 17507910
  12. Netrin G1 is not involved in atypical Rett syndrome or in unexplained encephalopathy with epilepsy, but in specific forms to be delineated better in the future. PMID: 17903671

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Tissue Specificity
Highly expressed in the thalamus, with very low expression, if any, in other tissues.
Database Links

HGNC: 23319

OMIM: 608818

KEGG: hsa:22854

STRING: 9606.ENSP00000359085

UniGene: Hs.133046

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