NUDT2 Antibody

Datasheet

Code	CSB-PA2105ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA2105ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA2105ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NUDT2 Polyclonal antibody

Uniprot No.

P50583

Target Names

NUDT2

Alternative Names

2310051L06Rik antibody; 5''''-P1 antibody; AA939917 antibody; Ap4A hydrolase 1 antibody; Ap4A hydrolase antibody; AP4A_HUMAN antibody; Ap4Aase antibody; APAH 1 antibody; APAH1 antibody; Bis(5' nucleosyl) tetraphosphatase [asymmetrical] antibody; Bis(5''-nucleosyl)-tetraphosphatase [asymmetrical] antibody; Diadenosine 5'' antibody; Diadenosine 5',5''' P1,P4 tetraphosphate asymmetrical hydrolase antibody; Diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase antibody; Diadenosine tetraphosphatase antibody; EC 3.6.1.17 antibody; MGC10404 antibody; Nucleoside diphosphate linked moiety X motif 2 antibody; Nucleoside diphosphate-linked moiety X motif 2 antibody; nudix (nucleoside diphosphate linked moiety X)-type motif 2 antibody; Nudix motif 2 antibody; Nudix-type motif 2 antibody; NUDT 2 antibody; NUDT2 antibody; OTTHUMP00000021256 antibody; OTTHUMP00000021257 antibody; OTTHUMP00000021258 antibody; OTTHUMP00000021259 antibody; P4-tetraphosphate asymmetrical hydrolase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Bis(5\\\'-nucleosyl)-tetraphosphatase [asymmetrical] protein (1-147AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP. Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro.

Gene References into Functions

NUDT2 is a novel complex formation enhancing factor regulating mTORC1-Rag GTPase signaling that is crucial for cell growth control. PMID: 28089905
Regulation of gene expression is one of several roles proposed for the stress-induced nucleotide diadenosine tetraphosphate (Ap4A). We have examined this directly by a comparative RNA-Seq analysis of KBM-7 chronic myelogenous leukemia cells and KBM-7 cells in which the NUDT2 Ap4A hydrolase gene had been disrupted (NuKO cells), causing a 175-fold increase in intracellular Ap4A. PMID: 27144453
This paper presents the crystal structure of wild-type and E58A mutant human Ap4A hydrolase. PMID: 23384440
High NUDT2 is associated with breast carcinoma. PMID: 20533549
In this study the authors present data demonstrating that the SARS-CoV 7a protein interacts with human Ap4A-hydrolase (asymmetrical diadenosine tetraphosphate hydrolase, EC 3.6.1.17). PMID: 20144233
crystallographic structure and substrate-binding mechanism of Ap4A hydrolase PMID: 15596429
NMR resonance assignments PMID: 15772762

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Protein Families

Nudix hydrolase family

Database Links

HGNC: 8049

OMIM: 602852

KEGG: hsa:318

STRING: 9606.ENSP00000338397

UniGene: Hs.493767

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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