NUP160 Antibody

1. Nup107-160 complex and its partner Elys dynamically colocalize with Nup98 and CRM1 into endogenous GLFG bodies present in specific HeLa sublines. PMID: 25904327
2. transcriptome sequencing of patient-derived angiosarcoma cells, identified a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined. PMID: 26527604
3. The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. PMID: 22031293
4. The interactions of Nup160 with Pom121 and are predicted to assist in the formation of the nuclear pore and the anchoring of the Nuclear pore complexes to the pore membrane. PMID: 20974814
5. A major function of the Nup107 complex in mitosis is to ensure the proper localization of the chromosome passenger complex at the centromere. PMID: 19864462
6. Data show that Nup107-160 promotes spindle assembly through Ran-GTP-regulated nucleation of microtubules by gamma-TuRC at kinetochores, and reveal a relationship between nucleoporins and the microtubule cytoskeleton. PMID: 20081840
7. Data show that structure-guided sequence comparison of Nup160 and Saccharomyces cerevisiae Nup120 strongly suggests that both proteins adopt the same unique fold despite a low sequence identity of 10%. PMID: 19576787
8. Nup107-160 complex is dynamic in mitosis and that it promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores. PMID: 16807356
9. phosphorylation does not affect interactions within the Nup107-160 subcomplex, but regulates the association of the subcomplex with the NPC and other proteins PMID: 17360435
10. These data thus provide the first molecular clues underlying the function of the human Nup107-160 complex at kinetochores. PMID: 17363900

Show More

Hide All

HGNC: 18017

OMIM: 607614

KEGG: hsa:23279

STRING: 9606.ENSP00000367721

UniGene: Hs.643526